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Logopenic progressive aphasia

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Main article: Aphasia

Logopenic progressive aphasia (LPA) is a form of primary progressive aphasia characterized by slow speech and impaired syntactic comprehension and naming.[1] It is similar to receptive aphasia and is associated with atrophy to the left posterior temporal cortex and inferior parietal lobule. It is suspected that an atypical form of Alzheimer's disease is the most common cause of logopenic progressive aphasia.[2][3]

Although patients with this the logopenic variant of PPA are still able to produce speech, their speech rate may be significantly slowed down due to word retrieval difficulty.[3] Over time, they may experience the inability to retain lengthy information, causing problems with understanding complex verbal information.[4]

A distinguishing symptom is a repetition of spared and impaired language processes seen in logopenic patients in comparison to patients suffering from other forms of progressive aphasia. Difficult in naming and repeating in motor speech, semantic, and syntactic abilities is one such specific challenge faced by patients of this disorder.

See Also Edit

References Edit

  1. Harciarek M, Kertesz A (September 2011). Primary progressive aphasias and their contribution to the contemporary knowledge about the brain-language relationship. Neuropsychol Rev 21 (3): 271–87.
  2. Henry ML, Gorno-Tempini ML (December 2010). The logopenic variant of primary progressive aphasia. Curr. Opin. Neurol. 23 (6): 633–7.
  3. 3.0 3.1 Gorno-Tempini ML, Hillis AE, Weintraub S, et al. (March 2011). Classification of primary progressive aphasia and its variants. Neurology 76 (11): 1006–14.
  4. UCSF Memory and Aging Center. (2011, February 22). SF: The Regents of the University of California. Retrieved December 5, 2011 from http://memory.ucsf.edu/education/diseases/ppa

Further ReadingEdit

  • Gorno-Tempini ML, Dronkers NF, Rankin KP, et al. (March 2004). Cognition and anatomy in three variants of primary progressive aphasia. Ann. Neurol. 55 (3): 335–46.
  • Rohrer JD, Knight WD, Warren JE, Fox NC, Rossor MN, Warren JD (January 2008). Word-finding difficulty: a clinical analysis of the progressive aphasias. Brain 131 (Pt 1): 8–38.


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