Lofepramine
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Lofepramine chemical structure | |
| IUPAC name | |
| CAS number [1] | ATC code [[ATC_code_|]][2] |
| PubChem 3947 | DrugBank [3] |
| Chemical formula | {{{chemical_formula}}} |
| Molecular weight | 418.958 g/mol |
| Bioavailability | |
| Metabolism | |
| Elimination half-life | |
| Excretion | |
| Pregnancy category | |
| Legal status | |
| Routes of administration | Oral |
Lofepramine (trademarked Gamanil) is a third generation tricyclic antidepressant used in the treatment of depressive disorders. It has both antidepressant and anxiolytic properties. Lofepramine is metabolized in vivo into desipramine; hence its pharmacological profile is extremely similar.
Indications
Edit
In the United Kingdom, lofepramine is licensed for the treatment of depression.
AvailabilityEdit
In the United Kingdom, lofepramine is marketed generically (as the hydrochloride salt) in the form of 70mg tablets.
DosageEdit
140-210mg daily in divided doses.
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