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{{Infobox Brain| |
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− | Name = |
+ | Name = Lateral geniculate nucleus | |
− | Latin = |
+ | Latin = Corpus geniculatum laterale | |
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+ | IsPartOf = [[Thalamus]]| |
+ | System = [[Visual system|Visual]]| |
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+ | Artery = [[Anterior choroidal artery|Anterior choroidal]] and [[Posterior cerebral artery|Posterior cerebral]]| |
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− | Artery = | |
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− | Vein = | |
+ | Vein = [[Terminal vein]]| |
BrainInfoType = hier | |
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BrainInfoNumber = 335 | |
BrainInfoNumber = 335 | |
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+ | NeuroLex = Lateral geniculate body |
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+ | | NeuroLexID = birnlex_1662 | |
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DorlandsPre = n_11 | |
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DorlandsSuf = 12581245 | |
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+ | The '''lateral geniculate nucleus''' ('''LGN''') is the primary relay center for [[Visual perception|visual]] information received from the [[retina]] of the [[Human eye|eye]]. The LGN is found inside the [[thalamus]] of the [[Human brain|brain]]. |
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+ | The LGN receives information directly from the ascending [[retinal ganglion cell]]s via the [[optic tract]] and from the [[reticular activating system]]. Neurons of the LGN send their axons through the [[optic radiation]], a direct pathway to the [[primary visual cortex]]. In addition, the LGN receives many strong feedback connections from the primary visual cortex.<ref name=Cudeiro2006>{{cite journal|last=Cudeiro|first=Javier|coauthors=Sillito, Adam M.|title=Looking back: corticothalamic feedback and early visual processing|journal=Trends in Neurosciences|year=2006|doi=10.1016/j.tins.2006.05.002|pages=298–306|volume=29|issue=6}}</ref> In [[mammals]], including [[humans]], the two strongest pathways linking the eye to the brain are those projecting to the LGNd (dorsal part of the LGN in the thalamus), and to the [[superior colliculus]] (SC).<ref>Goodale, M. & Milner, D. (2004)''Sight unseen.''Oxford University Press, Inc.: New York.</ref> |
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+ | Both the left and right [[Cerebral hemisphere|hemisphere]] of the brain have a lateral geniculate nucleus, named so for its resemblance to a bent knee (''genu'' is Latin for "knee"). In many [[primate]]s, including humans and [[macaque]]s, it has layers of cell bodies with layers of [[neuropil]] in between, in an arrangement something like a [[club sandwich]] or layer [[cake]], with cell bodies of LGN [[neuron]]s as the "cake" and [[neuropil]] as the "[[icing (food)|icing]]". In humans and macaques the LGN is normally described as having six distinctive layers. The inner two layers, 1 and 2, are called the magnocellular layers, while the outer four layers, 3, 4, 5, and 6, are called parvocellular layers. An additional set of neurons, known as the koniocellular sublayers, are found ventral to each of the magnocellular and parvocellular layers.<ref name="Carlson, N. R. 2007">Carlson, N. R. (2007)''Physiology of Behavior: ninth edition.''Pearson Education, Inc.: Boston.</ref> This layering is variable between primate species, and extra leafleting is variable within species. |
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⚫ | |||
+ | {| class="wikitable" |
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+ | | '''Type''' || '''Size*''' || '''Source / Type of Information''' || '''Location''' || '''Response''' || '''Number''' |
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+ | |- |
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+ | | M: [[Magnocellular cells]] || Large || Rods; necessary for the perception of ''' movement''', depth, and small differences in brightness || Layers 1 and 2 || rapid and transient || ? |
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+ | |- |
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+ | | P: [[Parvocellular cells]] (or "parvicellular") || Small || Cones; long- and medium-wavelength ("red" and "green" cones); necessary for the perception of '''color''' and form (fine details). || Layers 3, 4, 5 and 6 || slow and sustained || ? |
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+ | |- / |
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+ | | K: [[Koniocellular cells]] (or "interlaminar") || Very small cell bodies || Short-wavelength "blue" cones. || Between each of the M and P layers || || |
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+ | |} |
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− | + | [[Image:lateral geniculate nucleus.png|thumb|Schematic diagram of the primate LGN. Layers 1 and 2 are more ventrally located, and are next to the incoming optic tract fibers.]] |
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+ | *Size relates to cell body, dendritic tree and receptive field |
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⚫ | |||
− | The LGN receives information directly from the retina, and sends projections directly to the [[primary visual cortex]]. In addition, it receives many strong feedback connections from the primary visual cortex. |
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+ | Koniocellular cells are functionally and neurochemically distinct from M and P cells and provide a third channel to the visual cortex. They project their axons between the layers of the lateral geniculate nucleus where M and P cells project. Their role in visual perception is presently unclear; however, the koniocellular system has been linked with the integration of somatosensory system-proprioceptive information with visual perception, and it may also be involved in color perception.{{citation needed|date=January 2011}} |
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− | [[Ganglion cell]]s of the retina send [[axon]]s to the LGN through the [[optic nerve]]. Although it is generally considered to be a [[cranial nerve]], and is always listed as cranial nerve II, in reality the retina and optic nerve arise as an outpocketing of the developing [[diencephalon]]. Rather than a proper nerve, then, the optic nerve is really a [[tract]] of the brain. |
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+ | The parvo- and magnocellular fibers were previously thought to dominate the Ungerleider–Mishkin [[ventral stream]] and [[dorsal stream]], respectively. However, new evidence has accumulated showing that the two streams appear to feed on a more even mixture of different types of nerve fibers.<ref>Goodale & Milner, 1993, 1995.</ref> |
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⚫ | |||
+ | The other major retino–cortical visual pathway is the [[tectopulvinar pathway]], routing primarily through the [[superior colliculus]] and thalamic [[pulvinar]] nucleus onto [[posterior parietal]] cortex and [[visual area MT]]. |
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⚫ | |||
⚫ | |||
− | The LGN is a distinctively layered structure ("geniculate" means "bent like a knee"). In most primates, including humans, it has six layers of cell bodies with layers of [[neuropil]] in between, in an arrangement something like a club sandwich or layer cake, with cell bodies of LGN [[neuron]]s as the "cake" and [[neuropil]] as the "icing". |
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+ | Both the LGN in the right hemisphere and the LGN in the left hemisphere receive input from each eye. However, each LGN only receives information from one half of the visual field. This occurs due to axons of the ganglion cells from the inner halves of the retina (the nasal sides) decussating (crossing to the other side of the brain) through the optic chiasm (''khiasma'' means "cross"). The axons of the ganglion cells from the outer half of the retina (the temporal sides) remain on the same side of the brain. Therefore, the right hemisphere receives visual information from the left visual field, and the left hemisphere receives visual information from the right visual field. |
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⚫ | |||
+ | * the eye on the same side (the ''ipsilateral'' eye) sends information to layers 2, 3 and 5 |
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+ | * the eye on the opposite side (the ''contralateral'' eye) sends information to layers 1, 4 and 6. |
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+ | A simple [[mnemonic]] for remembering this is "See I? I see, I see," with "see" representing the C in "contralateral," and "I" representing the I in "ipsilateral." |
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− | These six layers contain two types of cells. The cells in layers 1 and 2 are large, or ''magnocellular'' (M); others in layers 3, 4, 5, and 6 are smaller, or ''parvocellular'' (P). (The [[Latin]] prefix "parvo-" means "small"; some authors prefer the term ''parvicellular''. If you're searching for more information, try both spellings.) |
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+ | Another way of remembering this is 2+3=5, which is correct, so ipsilateral side, and 1+4 doesn't equal 6, so contralateral. |
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− | Between each of the M and P layers lies a zone of very small cells: the interlaminar, or [[koniocellular]] (K), layers. K cells are functionally and neurochemically distinct from M and P cells and provide a third channel to the visual cortex. |
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+ | This description applies to the LGN of many primates, but not all. The sequence of layers receiving information from the ipsilateral and contralateral (opposite side of the head) eyes is different in the [[tarsier]].<ref>Rosa MG, Pettigrew JD, Cooper HM (1996) Unusual pattern of retinogeniculate projections in the controversial primate Tarsius. Brain Behav Evol 48(3):121–129.</ref> Some neuroscientists suggested that "this apparent difference distinguishes tarsiers from all other primates, reinforcing the view that they arose in an early, independent line of primate evolution".<ref>Collins CE, Hendrickson A, Kaas JH (2005) Overview of the visual system of Tarsius. Anat Rec A Discov Mol Cell Evol Biol 287(1):1013–1025.</ref> |
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⚫ | |||
− | [[Image:lateral_geniculate_nucleus.png|thumbnail|300px|right|Schematic diagram of the primate lateral geniculate nucleus.]] |
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⚫ | |||
⚫ | In [[visual perception]], the right eye gets information from the right side of the world (the right [[visual field]]), as well as the left side of the world (the left [[visual field]]). You can confirm this by covering your left eye: the right eye still sees to your left and right, although on the left side your field of view may be partially blocked by your nose. |
||
− | [[Magnocellular cells]] have large cell bodies, use a relatively short time to process information, and are part of a visual processing system that tells the brain ''where'' something is. This system operates quickly but without much detail. They are found in layers 1 and 2 of the LGN, those layers more [[ventral|ventrally]] located which are next to the incoming [[optic tract]] fibers. |
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⚫ | |||
− | M Cells are the retinal ganglion cells that project their axons to the magnocellular layers of the LGN. |
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⚫ | |||
− | [[Parvocellular cells]] have small cell bodies, use a relatively long time to process information, and are part of a visual processing system that tells the brain ''what'' something is. This system operates more slowly and with lots of information about details. For example, these cells carry [[color vision|color]] information while magnocellular cells do not. Parvocellular cells are found in layers 3, 4, 5 and 6. |
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+ | The LGN receives input from the retina. |
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+ | At least in some species, the LGN also receives some inputs from the [[optic tectum]] (also known as the [[superior colliculus]]).<ref>In Chapter 7, section "The Parcellation Hypothesis" of "Principles of Brain Evolution", [[Georg F. Striedter]] (Sinauer Associates, Sunderland, MA, USA, 2005) states, "...we now know that the LGN receives at least some inputs from the optic tectum (or superior colliculus) in many amniotes". He cites "Wild, J.M. 1989. Pretectal and tectal projections to the homolog of the dorsal lateral geniculate nucleus in the pigeon—an anterograde and retrograde tracing study with cholera-toxin conjugated to horseradish-peroxidase. Brain Res 489: 130–137" and also "Kaas, J.H., and Huerta, M.F. 1988. The subcortical visual system of primates. In: Steklis H. D., Erwin J., editors. Comparative primate biology, vol 4: neurosciences. New York: Alan Liss, pp. 327–391.</ref> |
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− | P Cells are the retinal ganglion cells that project their axons to the parvocellular layers of the LGN. |
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+ | == LGN output == |
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− | [[Koniocellular cells]] have very small cell bodies and are located in between the layers. They are also part of the system that tells the [[brain]] ''what'' something is; usually, their principal role is to determine [[color]]. |
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⚫ | |||
⚫ | The [[axon]]s that leave the LGN go to V1 [[visual cortex]]. Both the magnocellular layers 1–2 and the parvocellular layers 3–6 send their axons to layer 4 in V1. Within layer 4 of V1, layer 4cβ receives parvocellular input, and layer 4cα receives magnocellular input. However, the koniocellular layers (in between layers 1–6) send their axons to layers 4a in V1. [[Axon]]s from layer 6 of [[visual cortex]] send information back to the LGN. |
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− | K Cells are the retinal ganglion cells that project their axons to the koniocellular layers of the LGN. |
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+ | Studies involving [[blindsight]] have suggested that projections from the LGN not only travel to the primary visual cortex but also to higher cortical areas V2 and V3. Patients with blindsight are phenomenally blind in certain areas of the visual field corresponding to a contralateral lesion in primary visual cortex; however, these patients are able to perform certain motor tasks accurately in their blind field, such as grasping. This suggests that neurons travel from the LGN to both the visual cortex and higher cortex regions.<ref name=Schmid2010>{{cite journal|last=Schmid|first=Michael C.|coauthors=Mrowka, Sylwia W.; Turchi, Janita ''et al.''|title=Blindsight depends on the lateral geniculate nucleus|journal=Nature|year=2010|doi=10.1038/nature09179 |pages=373–377|volume=466|issue=7304}}</ref> |
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⚫ | |||
⚫ | |||
− | In addition, the layers are divided up so that the eye on the same side (the ''ipsilateral'' eye) sends information to layers 2, 3 and 5, while the eye on the opposite side (the ''contralateral'' eye) sends information to layers 1, 4 and 6. (A simple [[mnemonic]] for this is that 2 + 3 = 5 while 1 + 4 does not equal 6, so it is "contra"ry to your knowledge of math.) |
||
+ | The functions of the LGN are multiple. Its unique folding contributes to its utility by performing a range of anatomical calculations without requiring mathematical computations. These include both temporal correlations/decorrelations as well as spatial correlations. The resulting outputs include time correlated and spatially correlated signals resulting from summing the signals received from the left and right semifields of view captured by each of the two eyes. These signals are correlated in order to achieve a three-dimensional representation of object space as well as obtain information for controlling the precision (previously auxiliary) optical system (POS) of the visual modality. |
||
+ | The outputs serve several functions. |
||
⚫ | |||
+ | * A signal is provided to control the vergence of the two eyes so they converge at the principle plane of interest in object space. |
||
⚫ | |||
+ | * A signal is provided to control the focus of the eyes based on the calculated distance to the principle plane of interest. |
||
⚫ | |||
+ | * Computations are achieved to determine the position of every major element in object space relative to the principle plane. Through subsequent motion of the eyes, a larger stereoscopic mapping of the visual field is achieved.<ref>Lindstrom, S. & Wrobel, A. (1990) Intracellular recordings from binocularly activated cells in the cats dorsal lateral geniculate nucleus Acta Neurobiol Exp vol 50, pp 61–70</ref> |
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⚫ | |||
+ | ** A tag is provided for each major element in the central 1.2 degree field of view of object space. The accumulated tags are attached to the features in the merged visual fields forwarded to area 17 of the cerebral cortex (often described as the "primary" visual cortex or V1) |
||
+ | ** A tag is also provided for each major element in the visual field describing the velocity of the major elements based on its change in coordinates with time. |
||
+ | ** The velocity tags (particularly those associated with the peripheral field of view) are also used to determine the direction the organism is moving relative to object space. |
||
+ | These position and velocity tags are extracted prior to the information reaching area 17. They constitute the major source of information reported in [[blindsight]] experiments where an individual reports motion in a portion of the visual field associated with one hemisphere of area 17 that has been damaged by laceration, stroke, etc. |
||
⚫ | |||
+ | The output signals from the LGN determine the spatial dimensions of the stereoscopic and monoscopic portions of the horopter of the visual system.<ref>Fulton, J. (2004) Processes in Biological Vision Section 7.4 http://neuronresearch.net/vision/pdf/7Dynamics.pdf/</ref> |
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− | [[Axon]]s from layer 6 of [[visual cortex]] send information back to the LGN. |
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+ | It has been shown that while the retina accomplishes spatial [[decorrelation]] through center surround inhibition, the LGN accomplishes temporal decorrelation.<ref>Dawei W. Dong and Joseph J. Atick, Network—Temporal Decorrelation: A Theory of Lagged and Nonlagged Responses in the Lateral Geniculate Nucleus, 1995, pp. 159–178.</ref> This spatial–temporal decorrelation makes for much more efficient coding. However, there is almost certainly much more going on. |
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⚫ | |||
⚫ | Like other areas of the [[thalamus]], particularly other ''relay nuclei'', the LGN likely helps the [[visual system]] focus its attention on the most important information. That is, if you hear a sound slightly to your left, the [[auditory system]] likely "tells" the [[visual system]], through the LGN via its surrounding peri-reticular nucleus, to direct visual attention to that part of space.<ref>{{Cite pmid|16624964}}</ref> The LGN is also a station that refines certain [[receptive fields]].<ref>{{Cite pmid|22687612}}</ref> Experiments using [[fMRI]] in humans reported in 2010 that both spatial attention and [[saccade|saccadic eye movement]]s can modulate activity in the LGN.<ref>{{Cite pmid|20084170}}</ref> |
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− | The function of the LGN is unknown. It has been shown that the LGN introduces coding efficiencies by cancelling out redundant information from the [[retina]], but there is almost certainly much more going on. |
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+ | ==Additional images== |
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⚫ | Like other areas of the [[thalamus]], particularly other ''relay nuclei'', the LGN likely helps the [[visual system]] focus its attention on the most important information. That is, if you hear a sound slightly to your left, the [[auditory system]] likely "tells" the [[visual system]], through the LGN, to direct visual attention to that part of space. |
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+ | <gallery> |
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+ | Image:Constudthal.gif|Thalamus |
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+ | Image:Gray683.png|Dissection of brain-stem. Lateral view. |
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⚫ | |||
+ | Image:ThalamicNuclei.svg|Thalamic nuclei |
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+ | Image:ERP_-_optic_cabling.jpg|3D schematic representation of optic tracts |
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+ | </gallery> |
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⚫ | |||
− | The LGN is also a station that refines certain [[receptive fields]]. |
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+ | {{reflist}} |
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⚫ | |||
− | Recent experiments using [[fMRI]] in humans have found that both spatial attention and [[saccade|saccadic eye movement]]s can modulate activity in the LGN. |
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⚫ | |||
− | |||
⚫ | |||
⚫ | |||
⚫ | |||
− | *Harvey R. [http://www.utoronto.ca/cat/services/services_other/vizProjects/LGN.html Really cool movie of a 3D reconstruction of monkey LGN]. Retrieved September 1, 2004. |
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*Malpeli J. [http://soma.npa.uiuc.edu/labs/malpeli/home.html Malpeli Lab Home Page]. Retrieved September 1, 2004. |
*Malpeli J. [http://soma.npa.uiuc.edu/labs/malpeli/home.html Malpeli Lab Home Page]. Retrieved September 1, 2004. |
||
+ | *{{BrainMaps|lateral%20geniculate%20nucleus}} |
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⚫ | |||
+ | * {{UMichAtlas|eye_38}}—"The Visual Pathway from Below" |
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− | |||
+ | * {{BrainMaps|lgn}} |
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⚫ | |||
+ | * {{MedicalMnemonics|307|640||}} |
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− | * [http://brainmaps.org/index.php?q=lgn Brain Atlas, Brain Maps, Neuroinformatics] |
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+ | == See also == |
||
+ | * [[Medial geniculate nucleus]]—MGN processes auditory information |
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{{Visual_system}} |
{{Visual_system}} |
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− | {{ |
+ | {{Diencephalon}} |
+ | {{DEFAULTSORT:Lateral Geniculate Nucleus}} |
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[[Category:Cerebrum]] |
[[Category:Cerebrum]] |
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[[Category:Visual system]] |
[[Category:Visual system]] |
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+ | |||
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{{enWP|Lateral geniculate nucleus}} |
{{enWP|Lateral geniculate nucleus}} |
Revision as of 21:16, 18 May 2013
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Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)
Brain: Lateral geniculate nucleus | ||
---|---|---|
Hind- and mid-brains; postero-lateral view. (Lateral geniculate body visible near top.) | ||
[[Image:|250px|center|]] | ||
Latin | Corpus geniculatum laterale | |
Gray's | subject # | |
Part of | Thalamus | |
Components | ||
Artery | Anterior choroidal and Posterior cerebral | |
Vein | Terminal vein | |
BrainInfo/UW | hier-335 | |
MeSH | [1] |
The lateral geniculate nucleus (LGN) is the primary relay center for visual information received from the retina of the eye. The LGN is found inside the thalamus of the brain.
The LGN receives information directly from the ascending retinal ganglion cells via the optic tract and from the reticular activating system. Neurons of the LGN send their axons through the optic radiation, a direct pathway to the primary visual cortex. In addition, the LGN receives many strong feedback connections from the primary visual cortex.[1] In mammals, including humans, the two strongest pathways linking the eye to the brain are those projecting to the LGNd (dorsal part of the LGN in the thalamus), and to the superior colliculus (SC).[2]
Structure
Both the left and right hemisphere of the brain have a lateral geniculate nucleus, named so for its resemblance to a bent knee (genu is Latin for "knee"). In many primates, including humans and macaques, it has layers of cell bodies with layers of neuropil in between, in an arrangement something like a club sandwich or layer cake, with cell bodies of LGN neurons as the "cake" and neuropil as the "icing". In humans and macaques the LGN is normally described as having six distinctive layers. The inner two layers, 1 and 2, are called the magnocellular layers, while the outer four layers, 3, 4, 5, and 6, are called parvocellular layers. An additional set of neurons, known as the koniocellular sublayers, are found ventral to each of the magnocellular and parvocellular layers.[3] This layering is variable between primate species, and extra leafleting is variable within species.
M, P, K cells
Type | Size* | Source / Type of Information | Location | Response | Number |
M: Magnocellular cells | Large | Rods; necessary for the perception of movement, depth, and small differences in brightness | Layers 1 and 2 | rapid and transient | ? |
P: Parvocellular cells (or "parvicellular") | Small | Cones; long- and medium-wavelength ("red" and "green" cones); necessary for the perception of color and form (fine details). | Layers 3, 4, 5 and 6 | slow and sustained | ? |
K: Koniocellular cells (or "interlaminar") | Very small cell bodies | Short-wavelength "blue" cones. | Between each of the M and P layers |
- Size relates to cell body, dendritic tree and receptive field
The magnocellular, parvocellular, and koniocellular layers of the LGN correspond with the similarly named types of ganglion cells.
Koniocellular cells are functionally and neurochemically distinct from M and P cells and provide a third channel to the visual cortex. They project their axons between the layers of the lateral geniculate nucleus where M and P cells project. Their role in visual perception is presently unclear; however, the koniocellular system has been linked with the integration of somatosensory system-proprioceptive information with visual perception, and it may also be involved in color perception.[citation needed]
The parvo- and magnocellular fibers were previously thought to dominate the Ungerleider–Mishkin ventral stream and dorsal stream, respectively. However, new evidence has accumulated showing that the two streams appear to feed on a more even mixture of different types of nerve fibers.[4]
The other major retino–cortical visual pathway is the tectopulvinar pathway, routing primarily through the superior colliculus and thalamic pulvinar nucleus onto posterior parietal cortex and visual area MT.
Ipsilateral and contralateral layers
Both the LGN in the right hemisphere and the LGN in the left hemisphere receive input from each eye. However, each LGN only receives information from one half of the visual field. This occurs due to axons of the ganglion cells from the inner halves of the retina (the nasal sides) decussating (crossing to the other side of the brain) through the optic chiasm (khiasma means "cross"). The axons of the ganglion cells from the outer half of the retina (the temporal sides) remain on the same side of the brain. Therefore, the right hemisphere receives visual information from the left visual field, and the left hemisphere receives visual information from the right visual field. Within one LGN, the visual information is divided among the various layers as follows:[5]
- the eye on the same side (the ipsilateral eye) sends information to layers 2, 3 and 5
- the eye on the opposite side (the contralateral eye) sends information to layers 1, 4 and 6.
A simple mnemonic for remembering this is "See I? I see, I see," with "see" representing the C in "contralateral," and "I" representing the I in "ipsilateral."
Another way of remembering this is 2+3=5, which is correct, so ipsilateral side, and 1+4 doesn't equal 6, so contralateral.
This description applies to the LGN of many primates, but not all. The sequence of layers receiving information from the ipsilateral and contralateral (opposite side of the head) eyes is different in the tarsier.[6] Some neuroscientists suggested that "this apparent difference distinguishes tarsiers from all other primates, reinforcing the view that they arose in an early, independent line of primate evolution".[7]
In visual perception, the right eye gets information from the right side of the world (the right visual field), as well as the left side of the world (the left visual field). You can confirm this by covering your left eye: the right eye still sees to your left and right, although on the left side your field of view may be partially blocked by your nose.
In the LGN, the corresponding information from the right and left eyes is "stacked" so that a toothpick driven through the club sandwich of layers 1 through 6 would hit the same point in visual space six different times.
LGN inputs
The LGN receives input from the retina.
At least in some species, the LGN also receives some inputs from the optic tectum (also known as the superior colliculus).[8]
LGN output
Information leaving the LGN travels out on the optic radiations, which form part of the retrolenticular limb of the internal capsule.
The axons that leave the LGN go to V1 visual cortex. Both the magnocellular layers 1–2 and the parvocellular layers 3–6 send their axons to layer 4 in V1. Within layer 4 of V1, layer 4cβ receives parvocellular input, and layer 4cα receives magnocellular input. However, the koniocellular layers (in between layers 1–6) send their axons to layers 4a in V1. Axons from layer 6 of visual cortex send information back to the LGN.
Studies involving blindsight have suggested that projections from the LGN not only travel to the primary visual cortex but also to higher cortical areas V2 and V3. Patients with blindsight are phenomenally blind in certain areas of the visual field corresponding to a contralateral lesion in primary visual cortex; however, these patients are able to perform certain motor tasks accurately in their blind field, such as grasping. This suggests that neurons travel from the LGN to both the visual cortex and higher cortex regions.[9]
Function in visual perception
The functions of the LGN are multiple. Its unique folding contributes to its utility by performing a range of anatomical calculations without requiring mathematical computations. These include both temporal correlations/decorrelations as well as spatial correlations. The resulting outputs include time correlated and spatially correlated signals resulting from summing the signals received from the left and right semifields of view captured by each of the two eyes. These signals are correlated in order to achieve a three-dimensional representation of object space as well as obtain information for controlling the precision (previously auxiliary) optical system (POS) of the visual modality.
The outputs serve several functions.
- A signal is provided to control the vergence of the two eyes so they converge at the principle plane of interest in object space.
- A signal is provided to control the focus of the eyes based on the calculated distance to the principle plane of interest.
- Computations are achieved to determine the position of every major element in object space relative to the principle plane. Through subsequent motion of the eyes, a larger stereoscopic mapping of the visual field is achieved.[10]
- A tag is provided for each major element in the central 1.2 degree field of view of object space. The accumulated tags are attached to the features in the merged visual fields forwarded to area 17 of the cerebral cortex (often described as the "primary" visual cortex or V1)
- A tag is also provided for each major element in the visual field describing the velocity of the major elements based on its change in coordinates with time.
- The velocity tags (particularly those associated with the peripheral field of view) are also used to determine the direction the organism is moving relative to object space.
These position and velocity tags are extracted prior to the information reaching area 17. They constitute the major source of information reported in blindsight experiments where an individual reports motion in a portion of the visual field associated with one hemisphere of area 17 that has been damaged by laceration, stroke, etc.
The output signals from the LGN determine the spatial dimensions of the stereoscopic and monoscopic portions of the horopter of the visual system.[11]
It has been shown that while the retina accomplishes spatial decorrelation through center surround inhibition, the LGN accomplishes temporal decorrelation.[12] This spatial–temporal decorrelation makes for much more efficient coding. However, there is almost certainly much more going on.
Like other areas of the thalamus, particularly other relay nuclei, the LGN likely helps the visual system focus its attention on the most important information. That is, if you hear a sound slightly to your left, the auditory system likely "tells" the visual system, through the LGN via its surrounding peri-reticular nucleus, to direct visual attention to that part of space.[13] The LGN is also a station that refines certain receptive fields.[14] Experiments using fMRI in humans reported in 2010 that both spatial attention and saccadic eye movements can modulate activity in the LGN.[15]
Additional images
References
- ↑ Cudeiro, Javier, Sillito, Adam M. (2006). Looking back: corticothalamic feedback and early visual processing. Trends in Neurosciences 29 (6): 298–306.
- ↑ Goodale, M. & Milner, D. (2004)Sight unseen.Oxford University Press, Inc.: New York.
- ↑ Carlson, N. R. (2007)Physiology of Behavior: ninth edition.Pearson Education, Inc.: Boston.
- ↑ Goodale & Milner, 1993, 1995.
- ↑ Nicholls J., et al. From Neuron to Brain: Fourth Edition. Sinauer Associates, Inc. 2001.
- ↑ Rosa MG, Pettigrew JD, Cooper HM (1996) Unusual pattern of retinogeniculate projections in the controversial primate Tarsius. Brain Behav Evol 48(3):121–129.
- ↑ Collins CE, Hendrickson A, Kaas JH (2005) Overview of the visual system of Tarsius. Anat Rec A Discov Mol Cell Evol Biol 287(1):1013–1025.
- ↑ In Chapter 7, section "The Parcellation Hypothesis" of "Principles of Brain Evolution", Georg F. Striedter (Sinauer Associates, Sunderland, MA, USA, 2005) states, "...we now know that the LGN receives at least some inputs from the optic tectum (or superior colliculus) in many amniotes". He cites "Wild, J.M. 1989. Pretectal and tectal projections to the homolog of the dorsal lateral geniculate nucleus in the pigeon—an anterograde and retrograde tracing study with cholera-toxin conjugated to horseradish-peroxidase. Brain Res 489: 130–137" and also "Kaas, J.H., and Huerta, M.F. 1988. The subcortical visual system of primates. In: Steklis H. D., Erwin J., editors. Comparative primate biology, vol 4: neurosciences. New York: Alan Liss, pp. 327–391.
- ↑ Schmid, Michael C., Mrowka, Sylwia W.; Turchi, Janita et al. (2010). Blindsight depends on the lateral geniculate nucleus. Nature 466 (7304): 373–377.
- ↑ Lindstrom, S. & Wrobel, A. (1990) Intracellular recordings from binocularly activated cells in the cats dorsal lateral geniculate nucleus Acta Neurobiol Exp vol 50, pp 61–70
- ↑ Fulton, J. (2004) Processes in Biological Vision Section 7.4 http://neuronresearch.net/vision/pdf/7Dynamics.pdf/
- ↑ Dawei W. Dong and Joseph J. Atick, Network—Temporal Decorrelation: A Theory of Lagged and Nonlagged Responses in the Lateral Geniculate Nucleus, 1995, pp. 159–178.
- ↑ PMID 16624964 (PMID 16624964)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand - ↑ PMID 22687612 (PMID 22687612)
Citation will be completed automatically in a few minutes. Jump the queue or expand by hand - ↑ PMID 20084170 (PMID 20084170)
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External links
| Lateral geniculate nucleus
]]- Malpeli J. Malpeli Lab Home Page. Retrieved September 1, 2004.
- BrainMaps at UCDavis lateral%20geniculate%20nucleus
- Atlas of anatomy at UMich eye_38—"The Visual Pathway from Below"
- BrainMaps at UCDavis lgn
- Mnemonic at medicalmnemonics.com 307 640
See also
- Medial geniculate nucleus—MGN processes auditory information
Sensory system - Visual system - edit |
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Eye | Optic nerve | Optic chiasm | Optic tract | Lateral geniculate nucleus | Optic radiation | Visual cortex |
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