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The L-type calcium channel is a type of voltage-dependent calcium channel. Like the others of this class, the α1 subunit is the one that determines most of the channel's properties.
L-type calcium channel blockers are used as antiarrhythmics or antihypertensives, depending on whether the drugs has higher affinity to the heart (like verapamil) or to the vessels (nifedipine).
L-type channels are selectively blocked by dihydropyridines.
|Membrane transport protein: ion channels
||Voltage-dependent calcium channel (L-type/CACNA1C, N-type, P-type, Q-type, R-type, T-type) - Inositol triphosphate receptor - Ryanodine receptor - Cation channels of sperm
| Na: Sodium channel
|| Nav1.4 - Nav1.5 - Nav1.7 - Epithelial sodium channel
|K: Potassium channel
||Voltage-gated (KvLQT1, KvLQT2, KvLQT3, HERG, Shaker gene, KCNE1) - Calcium-activated (BK channel, SK channel) - Inward-rectifier (ROMK, KCNJ2) - Tandem pore domain
|Cl: Chloride channel
||Cystic fibrosis transmembrane conductance regulator
||Aquaporin (1, 2, 3, 4)
|Transient receptor potential
||TRPA - TRPC (TRPC6) - TRPM (TRPM6) - TRPML (Mucolipin-1) - TRPP - TRPV (TRPV1, TRPV6)
||Gap junction - Stretch-activated ion channel - Ligand-gated ion channel - Voltage-gated ion channel - Cyclic nucleotide-gated ion channel - Two-pore channel