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Karl Abraham collaborated with Freud on the understanding of manic-depressive illness, leading to Freud's paper on 'Mourning and Melancholia' in 1917. He was the analyst of Melanie Klein during 1924-1925, and of a number of other British psychoanalysts, including Edward Glover, James Glover, and Alix Strachey. He was a mentor for an influential group of German analysts, including Karen Horney, Helene Deutsh, and Franz Alexander.
- A considerable number of persons are able to protect themselves against the outbreak of serious neurotic phenomena only through intense work.
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