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Sir '''John Carew Eccles''' ([[January 27]], [[1903]] – [[May 2]], [[1997]]) was an [[Australia]]n [[neurophysiologist]] who won the [[1963]] [[Nobel Prize in Physiology or Medicine]] for his work on the [[synapse]]. He shared the prize together with [[Andrew Fielding Huxley]] and [[Alan Lloyd Hodgkin]].
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Sir '''John Carew Eccles''' (January 27, 1903 – May 2, 1997) was an Australian [[neurophysiologist]] who won the [[1963]] [[Nobel Prize in Physiology or Medicine]] for his work on the [[synapse]]. He shared the prize together with [[Andrew Fielding Huxley]] and [[Alan Lloyd Hodgkin]].
   
 
[[image:Eccles.jpg|thumb|John Eccles, shown here at his lab bench]]
 
[[image:Eccles.jpg|thumb|John Eccles, shown here at his lab bench]]
   
 
==Research==
 
==Research==
In the early [[1950s]], Eccles and his colleagues performed the key experiments that would win Eccles the Nobel Prize. To study synapses in the peripheral nervous system, Eccles and colleagues used the stretch [[reflex]] as a model. This reflex is easily studied because it consists of only two [[neuron]]s: a sensory neuron (the [[muscle spindle]] fiber) and the [[motor neuron]]. The sensory neuron synapses onto the motor neuron in the [[spinal cord]]. When Eccles passed a current into the sensory neuron in the [[quadriceps]], the motor neuron innervating the quadricep produced a small [[excitatory postsynaptic potential]] (EPSP). When he passed the same current through the [[hamstring]], the opposing muscle to the quadricep, he saw an [[inhibitory postsynaptic potential]] (IPSP) in the quadricep motor neuron. Although a single EPSP was not enough to fire an [[action potential]] in the motor neuron, the sum of several EPSPs from multiple sensory neurons synapsing onto the motor neuron could cause the motor neuron to fire, thus contracting the quadricep. On the other hand, IPSPs could subtract from this sum of EPSPs, preventing the motor neuron from firing.
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In the early 1950s, Eccles and his colleagues performed the key experiments that would win Eccles the Nobel Prize. To study synapses in the peripheral nervous system, Eccles and colleagues used the stretch [[reflex]] as a model. This reflex is easily studied because it consists of only two [[neuron]]s: a sensory neuron (the [[muscle spindle]] fiber) and the [[motor neuron]]. The sensory neuron synapses onto the motor neuron in the [[spinal cord]]. When Eccles passed a current into the sensory neuron in the [[quadriceps]], the motor neuron innervating the quadricep produced a small [[excitatory postsynaptic potential]] (EPSP). When he passed the same current through the [[hamstring]], the opposing muscle to the quadricep, he saw an [[inhibitory postsynaptic potential]] (IPSP) in the quadricep motor neuron. Although a single EPSP was not enough to fire an [[action potential]] in the motor neuron, the sum of several EPSPs from multiple sensory neurons synapsing onto the motor neuron could cause the motor neuron to fire, thus contracting the quadricep. On the other hand, IPSPs could subtract from this sum of EPSPs, preventing the motor neuron from firing.
   
Apart from these seminal experiments, Eccles was key to a number of important developments in [[neuroscience]]. Until around [[1949]], Eccles believed that [[synaptic transmission]] was primarily electrical rather than chemical. Although he was wrong in this hypothesis, his arguments led himself and others to perform some of the experiments which proved chemical synaptic transmission. [[Bernard Katz]] and Eccles worked together on some of the experiments which elucidated the role of [[acetylcholine]] as a [[neurotransmitter]].
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Apart from these seminal experiments, Eccles was key to a number of important developments in [[neuroscience]]. Until around 1949, Eccles believed that [[synaptic transmission]] was primarily electrical rather than chemical. Although he was wrong in this hypothesis, his arguments led himself and others to perform some of the experiments which proved chemical synaptic transmission. [[Bernard Katz]] and Eccles worked together on some of the experiments which elucidated the role of [[acetylcholine]] as a [[neurotransmitter]].
   
 
==Biography==
 
==Biography==
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[[Category:Australian neuroscientists|Eccles, John Carew]]
 
[[Category:Australian neuroscientists|Eccles, John Carew]]
[[Category:Australian Rhodes scholars|Eccles, John Carew]]
 
 
[[Category:Members of the Pontifical Academy of Sciences|Eccles]]
 
[[Category:Members of the Pontifical Academy of Sciences|Eccles]]
 
[[Category:Nobel Prize in Physiology or Medicine winners|Eccles, John Carew]]
 
[[Category:Nobel Prize in Physiology or Medicine winners|Eccles, John Carew]]
[[Category:University at Buffalo alumni|Eccles, John Carew]]
 
[[Category:University of Melbourne alumni|Eccles, John Carew]]
 
   
[[de:John Carew Eccles]]
 
[[fr:John Carew Eccles]]
 
[[it:John Carew Eccles]]
 
[[ja:ジョン・C・エックルス]]
 
[[pt:John Carew Eccles]]
 
 
{{enWP|John Carew Eccles}}
 
{{enWP|John Carew Eccles}}

Latest revision as of 17:06, July 31, 2006

Sir John Carew Eccles (January 27, 1903 – May 2, 1997) was an Australian neurophysiologist who won the 1963 Nobel Prize in Physiology or Medicine for his work on the synapse. He shared the prize together with Andrew Fielding Huxley and Alan Lloyd Hodgkin.

Eccles
John Eccles, shown here at his lab bench
Bri briAdded by Bri bri

ResearchEdit

In the early 1950s, Eccles and his colleagues performed the key experiments that would win Eccles the Nobel Prize. To study synapses in the peripheral nervous system, Eccles and colleagues used the stretch reflex as a model. This reflex is easily studied because it consists of only two neurons: a sensory neuron (the muscle spindle fiber) and the motor neuron. The sensory neuron synapses onto the motor neuron in the spinal cord. When Eccles passed a current into the sensory neuron in the quadriceps, the motor neuron innervating the quadricep produced a small excitatory postsynaptic potential (EPSP). When he passed the same current through the hamstring, the opposing muscle to the quadricep, he saw an inhibitory postsynaptic potential (IPSP) in the quadricep motor neuron. Although a single EPSP was not enough to fire an action potential in the motor neuron, the sum of several EPSPs from multiple sensory neurons synapsing onto the motor neuron could cause the motor neuron to fire, thus contracting the quadricep. On the other hand, IPSPs could subtract from this sum of EPSPs, preventing the motor neuron from firing.

Apart from these seminal experiments, Eccles was key to a number of important developments in neuroscience. Until around 1949, Eccles believed that synaptic transmission was primarily electrical rather than chemical. Although he was wrong in this hypothesis, his arguments led himself and others to perform some of the experiments which proved chemical synaptic transmission. Bernard Katz and Eccles worked together on some of the experiments which elucidated the role of acetylcholine as a neurotransmitter.

BiographyEdit

Eccles was born in Melbourne, Australia. He attended Melbourne High School and graduated from Melbourne University in 1925. He was awarded a Rhodes Scholarship to study under Charles Scott Sherrington at Oxford University, where he received his Doctor of Philosophy in 1929. In 1937 Eccles returned to Australia, where he worked on military research during World War II. After the war, he became a professor at the University of Otago in New Zealand. From 1952 to 1962 he worked as a professor at the Australian National University. He won the Australian of the Year Award in 1963, the same year he won the Nobel Prize. In 1966 he moved to the United States to work at the Institute for Biomedical Research in Chicago, Illinois. Unhappy with the working conditions there, he left to become a professor at the University at Buffalo from 1968 until he retired in 1975. After retirement, he moved to Switzerland and wrote on the mind-body problem. He died in 1997 in Locarno, Switzerland.

Eccles was a devout theist and a sometime Catholic, and is regarded by many Christians as an examplar of the successful melding of a life of science with one of faith. A biography states that, "although not always a practicing Catholic, Eccles was a theist and a spiritual person, and he believed 'that there is a Divine Providence operating over and above the materialistic happenings of biological evolution'... (Occasionally, if Eccles found himself in strange surroundings on a Sunday, he would go to some pains to find a church where he could attend a Mass.)"

BibliographyEdit

External linksEdit

Preceded by:
Alexander 'Jock' Sturrock
Australian of the Year
1963
Succeeded by:
Dawn Fraser
This page uses Creative Commons Licensed content from Wikipedia (view authors).

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