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Image:Isoproterenol.png Isoproterenol
4-[1-hydroxy-2-(1-methylethylamino) ethyl] benzene-1,2-diol IUPAC name
CAS number 7683-59-2	ATC code C01CA02 .
PubChem 3779	DrugBank APRD00182
Chemical formula	{{{chemical_formula}}}
Molecular weight	211.258 g/mol
Bioavailability
Metabolism
Elimination half-life
Excretion	{{{excretion}}}
Pregnancy category
Legal status
Routes of administration	inhaled 80-120μg

Isoproterenol hydrochloride or isoprenaline (Medihaler-Iso®) is a sympathomimetic beta adrenergic receptor agonist medication, used as an inhaled aerosol to treat asthma. Although it activates all beta adrenergic receptors, it works in a similar fashion to the more selective beta2-adrenergic receptor agonists e.g. salbutamol, by relaxing the airways to increase airflow.

It is also supplied in ampules under the brand name Isuprel® for injection and in sublingual pill form for treatment of asthma, chronic bronchitis and emphysema.

It is structurally similar to epinephrine but acts for the most part on beta receptors.

[edit] Pharmacological details

Isoprenaline is a synthetic derivative of noradrenaline that is not found in the body. It is also known as Isoproterenol.

It is a β₁ and β₂-adrenoceptor agonist which was commonly used to treat asthma before the more widespread use of salbutamol, which has more selective effects on the airways. Its route of administration is either intravaneous, oral, intranasal, subcutaneous or intramuscular depending on use.

Isoprenaline is a sympathomimetic agent and is a non-selective β-adrenoceptor agonist. It has unwanted side effects which include tachycardia and dysrhythmias that result from activation of β₁ receptors in the heart. The plasma half life for isoprenaline is about 2 hours.

Stimulation of β₁-adrenoceptors also leads to enhancing of phase 4 depolarisation in SA nodal cells, increasing the pacemaker potential (leading to increased frequency of contraction-chronotropy)

[edit] Warnings and Contraindications

Isoproterenol should not be administered to patients with myocardial ischaemia.

This box: view • talk • edit Adrenergic and dopaminergic agents (C01CA)
Dobutamine • Dopamine • Epinephrine • Fenoldopam • Isoprenaline • Metaraminol • Midodrine • Norepinephrine • Octopamine • Phenylephrine

v·d·e Drugs for obstructive airway diseases: asthma/COPD (R03)
Adrenergics, inhalants	Short acting β2-agonists: Salbutamol/Levosalbutamol • Fenoterol • Terbutaline Long acting β2-agonists (LABA): Bambuterol • Clenbuterol • Formoterol • Salmeterol other: Epinephrine • Isoproterenol • Orciprenaline
Glucocorticoids	Beclometasone • Budesonide • Ciclesonide • Fluticasone • Mometasone
Anticholinergics	Ipratropium • Tiotropium
Mast cell stabilizers	Cromoglicate • Nedocromil
Xanthines	Aminophylline • Theobromine • Theophylline
Leukotriene antagonists	Montelukast • Pranlukast • Zafirlukast
Combination products	Budesonide/formoterol • Fluticasone/salmeterol • Ipratropium/salbutamol

This page uses content from the English-language version of Wikipedia. The original article was at Isoproterenol. The list of authors can be seen in the page history. As with Psychology Wiki, the text of Wikipedia is available under the GNU Free Documentation License.