Isocarboxazid

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File:Isocarboxazid structure.svg Isocarboxazid
N'-benzyl-5-methyl-oxazole-3-carbohydrazide IUPAC name
CAS number 59-63-2	ATC code N06AF01
PubChem 3759	DrugBank APRD00701
Chemical formula	{{{chemical_formula}}}
Molecular weight	231.26
Bioavailability	?
Metabolism	Liver
Elimination half-life	?
Excretion	Urine
Pregnancy category	C (USA)
Legal status	Rx-only
Routes of administration	Oral

Isocarboxazid is a nonselective hydrazine-derived monoamine oxidase inhibitor used in treatment resistant depression.

Contents 1 Uses 1.1 Approved 1.2 Off-Label/Unapproved/Investigational 2 Brand Names 2.1 United States 2.2 United Kingdom 3 References

[edit] Uses

[edit] Approved

In the United States, isocarboxazid is approved for the treatment of depression.

In the United Kingdom, isocarboxazid is licensed for the treatment of depression unresponsive to selective serotonin reuptake inhibitors (SSRIs).

[edit] Off-Label/Unapproved/Investigational

A randomized controlled trial published in December of 1988 found that isocarboxazid significantly reduced bingeing and purging in bulimia nervosa, regardless of the presence or absence of depression or personality disorder.^[1]

[edit] Brand Names

[edit] United States

MARPLAN® by Hoffmann-La Roche, starting in 1959 and discontinuing in 1994. After much patient and physician outcry, they resumed manufacturing just enough Marplan® to distribute on an as-needed basis. In October of 1998, Hoffmann-La Roche and Oxford Pharmaceutical Services Inc. announced that Oxford, "is acquiring ownership of the NDA for the antidepressant product Marplan® (isocarboxazid) from Roche."^[2]

The maximum daily dose of isocarboxazid is 60mg.

[edit] United Kingdom

Isocarboxazid is availably generically in the United Kingdom in the form of 10mg tablets. However, it is considered 'less suitable for prescribing' by the British National Formulary (BNF).

[edit] References

• drugs.com Isocarboxazid Drug Information
• Monoamine-oxidase inhibitors (Group PIM G025) IPCS INTOX Databank
• PubChem Substance Summary: Isocarboxazid National Center for Biotechnology Information.

1. ^  Kennedy SH, Piran N, Warsh JJ, Prendergast P, Mainprize E, Whynot C, Garfinkel PE. "A trial of isocarboxazid in the treatment of bulimia nervosa." Journal of Clinical Psychopharmacology. 1988 Dec;8(6):391-6. PMID 3069879
2. ^  Marplan Press Release Oxford Pharmaceutical Services.

Antidepressants (ATC N06A) edit
Monoamine oxidase inhibitors (MAOI)	Harmaline, Iproclozide, Iproniazid, Isocarboxazid, Nialamide, Phenelzine, Selegiline, Toloxatone, Tranylcypromine
Reversible inhibitor of monoamine oxidase A (RIMA)	Brofaromine, Moclobemide
Dopamine reuptake inhibitor (DARI)	Amineptine, Phenmetrazine, Vanoxerine, Modafinil
Norepinephrine-dopamine reuptake inhibitors	Bupropion
Norepinephrine reuptake inhibitor (NRI) or (NARI)	Atomoxetine, Maprotiline, Reboxetine, Viloxazine
Serotonin-norepinephrine reuptake inhibitor (SNRI)	Duloxetine, Milnacipran, Venlafaxine
Selective serotonin reuptake inhibitor (SSRI)	Alaproclate, Etoperidone, Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Zimelidine
Selective serotonin reuptake enhancer (SSRE)	Tianeptine
Tricyclic antidepressants (TCA)	Amitriptyline, Amoxapine, Butriptyline, Clomipramine, Desipramine, Dibenzepin, Dothiepin, Doxepin, Imipramine, Iprindole, Lofepramine, Melitracen, Nortriptyline, Opipramol, Protriptyline, Trimipramine
Tetracyclic antidepressants	Maprotiline, Mianserin, Nefazodone, Trazodone
Noradrenergic and specific serotonergic antidepressant (NaSSA) Mirtazapine

CategoryAmine oxidase inhibitors

This page uses content from the English-language version of Wikipedia. The original article was at Isocarboxazid. The list of authors can be seen in the page history. As with Psychology Wiki, the text of Wikipedia is available under the GNU Free Documentation License.