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In humans, it is a mild form of suffering, often with anger about this, in particular, if applicable, anger at the person who caused it. This can also be oneself, e.g. when forgetting something or doing something one deems to be stupid.
It is a form of stress, but conversely, if one is stressed by unrelated matters, mild imperfections can cause more irritation than usual, one is irritable; see also sensitivity (human).
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