Inositol triphosphate receptor
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| inositol 1,4,5-triphosphate receptor, type 1 | |
|---|---|
| Symbol(s): | ITPR1 |
| Locus: | 3 p26.1 |
| EC number | [1] |
| EntrezGene | 3708 |
| OMIM | 147265 |
| RefSeq | NM_002222 |
| UniProt | Q14643 |
| inositol 1,4,5-triphosphate receptor, type 2 | |
|---|---|
| Symbol(s): | ITPR2 |
| Locus: | 12 p11.23 |
| EC number | [2] |
| EntrezGene | 3709 |
| OMIM | 600144 |
| RefSeq | NM_002223 |
| UniProt | Q14571 |
| inositol 1,4,5-triphosphate receptor, type 3 | |
|---|---|
| Symbol(s): | ITPR3 |
| Locus: | 6 p21.31 |
| EC number | [3] |
| EntrezGene | 3710 |
| OMIM | 147267 |
| RefSeq | NM_002224 |
| UniProt | Q14573 |
Inositol triphosphate receptor (IP3R) is a membrane glycoprotein complex acting as Ca2+ channel activated by inositol triphosphate (IP3).
Contents |
Distribution
Edit
It has a broad tissue distribution but is especially abundant in the cerebellum. Most of the IP3R's are found in the cell integrated into the endoplasmic reticulum.
StructureEdit
The IP3R complex is formed of four 313 kDa subunits. There are 3 isoforms and these can form homo- or hetero-oligomers.
See alsoEdit
- inositol
- inositol phosphate
- myo-inositol (inositol monophosphate).
- inositol triphosphate
- inositol pentakisphosphate
- inositol hexaphosphate
External linksEdit
 | This protein-related article is a stub. You can help Wikipedia by expanding it. |
Cell signaling: lipid signaling |
|---|
|
Phospholipase - PIP2 - DAG - IP3 - IP3 receptor |
Membrane transport protein: ion channels
| |
|---|---|
| Ca | Voltage-dependent calcium channel (L-type/CACNA1C, N-type, P-type, Q-type, R-type, T-type) - Inositol triphosphate receptor - Ryanodine receptor - Cation channels of sperm |
| Na: Sodium channel | Nav1.4 - Nav1.5 - Nav1.7 - Epithelial sodium channel |
| K: Potassium channel | Voltage-gated (KvLQT1, KvLQT2, KvLQT3, HERG, Shaker gene, KCNE1) - Calcium-activated (BK channel, SK channel) - Inward-rectifier (ROMK, KCNJ2) - Tandem pore domain |
| Cl: Chloride channel | Cystic fibrosis transmembrane conductance regulator |
| Porin | Aquaporin (1, 2, 3, 4) |
| Transient receptor potential | TRPA - TRPC (TRPC6) - TRPM (TRPM6) - TRPML (Mucolipin-1) - TRPP - TRPV (TRPV1, TRPV6) |
| Other/general | Gap junction - Stretch-activated ion channel - Ligand-gated ion channel - Voltage-gated ion channel - Cyclic nucleotide-gated ion channel - Two-pore channel |
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