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Inositol triphosphate receptor

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inositol 1,4,5-triphosphate receptor, type 1
Symbol(s): ITPR1
Locus: 3 p26.1
EC number [1]
EntrezGene 3708
OMIM 147265
RefSeq NM_002222
UniProt Q14643
inositol 1,4,5-triphosphate receptor, type 2
Symbol(s): ITPR2
Locus: 12 p11.23
EC number [2]
EntrezGene 3709
OMIM 600144
RefSeq NM_002223
UniProt Q14571
inositol 1,4,5-triphosphate receptor, type 3
Symbol(s): ITPR3
Locus: 6 p21.31
EC number [3]
EntrezGene 3710
OMIM 147267
RefSeq NM_002224
UniProt Q14573

Inositol triphosphate receptor (IP3R) is a membrane glycoprotein complex acting as Ca2+ channel activated by inositol triphosphate (IP3).


It has a broad tissue distribution but is especially abundant in the cerebellum. Most of the IP3R's are found in the cell integrated into the endoplasmic reticulum.


The IP3R complex is formed of four 313 kDa subunits. There are 3 isoforms and these can form homo- or hetero-oligomers.

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