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Alpha inhibin
Symbol(s): INHA
Genetic data
Locus: Chr. 2 q33-qter
Database Links
Entrez: 3623
OMIM: 147380
RefSeq: NM_002191
UniProt: P05111

Assessment | Biopsychology | Comparative | Cognitive | Developmental | Language | Individual differences | Personality | Philosophy | Social |
Methods | Statistics | Clinical | Educational | Industrial | Professional items | World psychology |

Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)


inhibin, beta A
Symbol(s): INHBA
Genetic data
Locus: Chr. 7 p15-p13
Database Links
Entrez: 3624
OMIM: 147290
RefSeq: NM_002192
UniProt: P08476

Assessment | Biopsychology | Comparative | Cognitive | Developmental | Language | Individual differences | Personality | Philosophy | Social |
Methods | Statistics | Clinical | Educational | Industrial | Professional items | World psychology |

Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)


inhibin, beta B
Symbol(s): INHBB
Genetic data
Locus: Chr. 2 cen-q13
Database Links
Entrez: 3625
OMIM: 147390
RefSeq: NM_002193
UniProt: P09529

Inhibin is a peptide that is an inhibitor of FSH synthesis and secretion, and participates in the regulation of the menstrual cycle.

StructureEdit

Inhibin contains an alpha and beta subunit linked by disulfide bonds. Two forms of inhibin differ in their beta subunits (A or B), while their alpha subunits are identical. Inhibin belongs to the transforming growth factor-β (TGF-β) family.

ActionEdit

In women, FSH stimulates the secretion of inhibin from the granulosa cells of the ovary. In turn, inhibin suppresses FSH. Inhibin secretion is diminished by GnRH, and enhanced by insulin-like growth factor-1 (IGF-1). Inhibin B reaches a peak in the early- to mid-follicular phase, and a second peak at ovulation, in contrast to inhibin A, which reaches its peak in the mid-luteal phase. Inhibin is produced in the gonads, pituitary gland, placenta and other organs.

In men, it is a hormone that inhibits FSH production. It is secreted from the sustentacular cell, located in the seminiferous tubule inside the testes.

ActivinEdit

Activin is a related peptide that counteracts inhibin.

Prenatal TestingEdit

Quantification of inhibin A is part of the prenatal quad screen that can be administered during pregnancy at a gestational age of 16-18 weeks. An elevated inhibin A (along with an increased beta-hCG, decreased AFP, and a decreased estriol) is [1] suggestive of the presence of a fetus with Downs syndrome. As a screening test, abnormal quad screen test results need to be followed up with more definitive tests.

External linksEdit

ReferencesEdit

  1. , David A. Aitken, Ph.D., Euan M. Wallace, M.R.C.O.G., Jennifer A. Crossley, Ph.D., Ian A. Swanston, B.Sc., Yvonne van Pareren, M.Sc., Merel van Maarle, M.Sc., Nigel P. Groome, Ph.D., James N. Macri, Ph.D., and J. Michael Connor, M.D. (1996-05-09)Dimeric Inhibin A as a Marker for Down's Syndrome in Early Pregnancy. New England Journal of Medicine, The 334 (19): 1231-1236.


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Target-derived NGF, BDNF, NT-3

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