Ad blocker interference detected!
Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers
Wikia is not accessible if you’ve made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected.
Individual differences |
Methods | Statistics | Clinical | Educational | Industrial | Professional items | World psychology |
Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)
The indirect pathway of movement is a neuronal circuit through the basal ganglia and several associated nuclei within the central nervous system (CNS) which helps to prevent unwanted muscle contractions from competing with voluntary movements. It operates in conjunction with the direct pathway of movement.
Overview of Neuronal Connections and Normal Function Edit
The indirect pathway passes through the caudate, putamen, and globus pallidus, which are parts of the basal ganglia. It traverses the subthalamic nucleus, a part of the diencephalon, and enters the substantia nigra, a part of the midbrain. In a resting individual, a specific region of the globus pallidus, known as the internus, and a portion of the substantia nigra, known as the pars reticulata, send spontaneous inhibitory signals to the ventrolateral nucleus of the thalamus, through the release of GABA, an inhibitory neurotransmitter. Inhibition of the excitatory neurons within VL, which project to the motor regions of the cerebral cortices of the telencephalon, leads to a reduction of activity in the motor cortices, and a lack of muscular action.
When the pre-frontal region of the cerebral cortex, which is generally involved in decision making and planning, determines that motor activity be executed, it sends activating signals to the motor cortices. The motor cortices send activating signals to the direct pathway through the basal ganglia, which stops inhibitory outflow from parts of the globus pallidus internus and the substantia nigra pars reticulata. The net effect is to allow the activation of the ventrolateral nucleus of the thalamus which, in turn, sends activating signals to the motor cortices. These events amplify motor cortical activity that will eventually drive muscle contractions.
Simultaneously, in the indirect pathway, the motor cortices send activating signals to the caudate and putamen. The cells of the indirect pathway in the caudate and putamen that receive these signals are inhibitory and, once activated, they send inhibitory signals to the globus pallidus externus, reducing the activity in that nucleus. The globus pallidus externus normally sends inhibitory signals to the subthalamic nucleus. On activation of the indirect pathway, these inhibitory signals are reduced, which allows more activation of the subthalamic nucleus. Subthalamic nucleus cells can then send more activating signals to some parts of the globus pallidus internus and substantia nigra pars reticulata. Thus, parts of these two nuclei are driven to send more inhibitory signals to the ventrolateral nucleus of the thalamus, which prevents the development of significant activity in the motor cerebral cortices. This behavior prevents the activation of motor cortical areas that would compete with the voluntary movement.
Diseases Involving the Indirect Pathway Edit
Interruption or dysfunction of the indirect pathway of movement results in hyperkinesia, or dyskinesias, which are, in general, diseases which lead to the production of additional involuntary muscle activity.
- ↑ Nambu, A. A new dynamic model of the cortico-basal ganglia loop. Prog Brain Res. 2004; 143: 461-466
- ↑ Pollack AE. Anatomy, physiology, and pharmacology of the basal ganglia. Neurol Clin. 2001; 19: 523-534.
- ↑ Hauber W. Involvement of basal ganglia transmitter systems in movement initiation. Prog Neurobiol. 1998; 45: 507-540.
- ↑ Bolam J, Hanley J, Booth P, et al. Synaptic organization of the basal ganglia. J Anat. 2000; 196: 527-542.
|This page uses Creative Commons Licensed content from Wikipedia (view authors).|