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Indiplon

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Indiplon chemical structure
Indiplon

N-methyl-N-[3-[3-(thiophene-2-carbonyl)
pyrazolo[5,1-b]pyrimidin-7-yl]phenyl]acetamide
IUPAC name
CAS number
325715-02-4
ATC code

[[ATC_code_|]][1]

PubChem
6450813
DrugBank
[2]
Chemical formula {{{chemical_formula}}}
Molecular weight 376.0993
Bioavailability
Metabolism
Elimination half-life
Excretion
Pregnancy category {{{pregnancy_category}}}
Legal status {{{legal_status}}}
Routes of administration Oral


Indiplon (INN and USAN) is a nonbenzodiazepine, hypnotic sedative being developed in 2 formulations - an immediate release product for sleep onset and a modified-release version for sleep maintenance.

Mode of action Edit

Indiplon is said to work by enhancing the action of the inhibitory neurotransmitter GABA, like most other nonbenzodiazepine sedatives. It primarily binds to the α1 subunits of the GABAA receptors in the brain.[1]

AvailabilityEdit

Indiplon was originally scheduled for release to doctors and pharmacies sometime in 2007, most likely in the springtime of that year, which is when Sanofi-Aventis' popular sleep aid, zolpidem, lost its patent rights in the United States and thus became available to patients as a much less expensive generic. Neurocrine Biosciences had planned to comarket indiplon in the US with Pfizer. However, following the issuing of a nonapprovable letter for the modified-release 15mg formulation and an approvable letter (with stipulations) for the 5mg and 10mg immediate-release version by the FDA (May 2006), Pfizer decided to end its relationship with Neurocrine.[How to reference and link to summary or text]

On December 13, 2007, Neurocrine announced that the FDA deemed their new drug application (NDA) 'approvable'.[2] The 2007 Approvable Letter does not reference the setbacks seen previously in the May 2006 Approvable Letter, bringing the availability of indiplon one step closer to the consumer.[2]

The planned brand name has not yet been revealed to the public. The NDA was initially approved by the FDA in 1998,[How to reference and link to summary or text] and since then, Neurocrine has been conducting clinical trials, with purportedly satisfactory results.[How to reference and link to summary or text]

CarcinogenicityEdit

A recent analysis of FDA and clinical trial data shows that nonbenzodiazepine Z-drugs cause cancer in humans. The data shows that trial subjects receiving hypnotic drugs had an increased the risk of developing cancer and malignancies. There have been 15 epidemiologic studies which have shown that hypnotic drugs cause increased mortality, mainly due to increased cancer deaths. The cancers included cancer of the brain, lung, bowel, breast, and bladder, and neoplasms. Initially FDA reviewers did not want to approve the drugs due to concerns of cancer but ultimately changed their mind and approved the drugs despite the concerns. FDA data has shown that zolpidem, zaleplon and eszopiclone are clastogenic and cause cancer in rodents. Benzodiazepine agonists are associated with an increased risk of ovarian cancer in humans. Zopiclone was reportedly refused a product license by the FDA due to indications that zopiclone caused cancer. Development of a malignant neoplasm has been associated with zolpidem usage but the rate of incidence of neoplasm in zolpidem users is as yet unknown. The rates, in clinical trials for the nonbenzodiazepine Z drugs, of malignancies and neoplasms are significantly higher in hypnotic groups than in placebo groups. Also the analysis of clinical trials and FDA data showed that eszopiclone, zaleplon, and zolpidem appeared to have an adverse effect on the immune system causing an increased rate of infections and colds in hypnotic users. Suppression of immune function might be the cause of the increased rate of cancer in nonbenzodiazepine hypnotic users. Indiplon has also shown an increased rate of cancers in clinical trials. The review author concluded saying; "the likelihood of cancer causation is sufficiently strong now that physicians and patients should be warned that hypnotics possibly place patients at higher risk for cancer".[3]

ReferencesEdit

  1. Petroski RE, Pomeroy JE, Das R, et al (April 2006). Indiplon is a high-affinity positive allosteric modulator with selectivity for alpha1 subunit-containing GABAA receptors. J. Pharmacol. Exp. Ther. 317 (1): 369–77.
  2. 2.0 2.1 Neurocrine Biosciences, Inc. (2007-12-13). Neurocrine Receives Approvable Letter for Indiplon Capsules with Additional Safety and Efficacy Data Required by FDA. Press release. Retrieved on 2007-12-13.
  3. Kripke, Daniel F (2008). Evidence That New Hypnotics Cause Cancer. Department of Psychiatry, UCSD.

External linksEdit



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