Hypothalamic-pituitary dysfunction

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Hypothalamic-pituitary dysfunction

ICD-10	E233
ICD-9
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Hypothalamic-pituitary dysfunction is a term to describe a nonorganic relative inactivity of the gonadotropin-releasing hormone (GnRH) system of the hypothalamus and its dependent pituitary gonadotrophs that normally produce follicle stimulating hormone, FSH, and luteinizing hormone, LH. The condition occurs during the reproductive years and leads to hypogonadotropic hypogonadism. Women will experience primary or secondary amenorrhea and men lack of sexual interest and impotence.

The immediate cause is a decrease or lack of GnRH pulses. This may occur idiopathic, or as a result of stress or lack of caloric support. Eating disorders may lead to hypothalamic-pituitary dysfunction. Measurements of FSH and/or LH tend to show low or undetectable values, and sex hormones produced by the gonads show low levels as well. Hyperprolactinemia as well as a number of lesions in the hypothalamic or pituitary area may also lead to hypogonadotropic hypogonadism and need to be excluded before the diagnosis of hypothalamic-pituitary dysfunction can be made.

Treatment may need to address issues of hypogonadism, infertility, and osteoporosis.

v·d·e Endocrine pathology of psychological interest (E00-35)

thyroid Hypothyroidism (Iodine deficiency, Cretinism, Congenital hypothyroidism, Goitre) - Hyperthyroidism (Graves-Basedow disease, Toxic multinodular goitre) - Thyroiditis (De Quervain's thyroiditis, Hashimoto's thyroiditis) pancreas Diabetes mellitus (type 1, type 2, coma, angiopathy, neuropathy, retinopathy) - Zollinger-Ellison syndrome parathyroid Hypoparathyroidism - Hyperparathyroidism pituitary hyperfunction (Acromegaly, Hyperprolactinaemia, ) - Hypopituitarism Kallmann syndrome, Growth hormone deficiency) - Hypothalamic-pituitary dysfunction adrenal Cushing's syndrome) - Congenital adrenal hyperplasia (due to 21-hydroxylase deficiency) - Bartter syndrome) - Adrenal insufficiency (Addison's disease) gonads - 5-alpha-reductase deficiency - Hypogonadism - Delayed puberty - Precocious puberty other - - Psychogenic dwarfism - Androgen insensitivity syndrome -

This page uses content from the English-language version of Wikipedia. The original article was at Hypothalamic-pituitary dysfunction. The list of authors can be seen in the page history. As with Psychology Wiki, the text of Wikipedia is available under the GNU Free Documentation License.