Hypothalamic-pituitary-thyroid axis

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The hypothalamic-pituitary-thyroid axis (HPT axis for short) is part of the endocrine system responsible for the regulation of metabolism.

As its name suggests, it depends upon the hypothalamus, the pituitary gland, and the thyroid gland.

The hypothalamus senses low circulating levels of thyroid hormone (T3 and T4) and responds by releasing thyrotropin releasing hormone (TRH). The TRH stimulates the pituitary to produce thyroid stimulating hormone (TSH). The TSH, in turn, stimulates the thyroid to produce thyroid hormone until levels in the blood return to normal. Thyroid hormone exerts negative feed back control over the hypothalamus as well as anterior pituitary thus controlling the release of both TRH from hypothalamus and TSH from anterior pituitary gland

v·d·e Human anatomy, endocrine system: endocrine glands
Hypothalamic/ pituitary axes	v·d·e Thyroid axis Thyroid gland (Parafollicular cell, Thyroid epithelial cell, Thyroid isthmus, Lobes of thyroid gland, Pyramid of thyroid) Parathyroid gland (Oxyphil cell, Chief cell) Adrenal axis: Adrenal gland v·d·e Medulla Chromaffin cells Cortex Zona glomerulosa · Zona fasciculata · Zona reticularis Paraganglia Organ of Zuckerkandl · Aortic body · Carotid body Gonadal axis Testes · Ovaries · Corpus luteum Pituitary v·d·e Posterior pituitary Pars nervosa · Median eminence · Infundibular stalk · Pituicyte · Herring bodies Anterior pituitary Pars intermedia · Pars tuberalis · Pars distalis · Acidophils (Somatotropes, Lactotropes) · Basophils (Corticotropes, Gonadotropes, Thyrotropes)
Pineal gland	Pinealocyte · Corpora arenacea
Islets of pancreas	Alpha cell · Beta cell · Delta cell · PP cell · Epsilon cell

This page uses content from the English-language version of Wikipedia. The original article was at Hypothalamic-pituitary-thyroid axis. The list of authors can be seen in the page history. As with Psychology Wiki, the text of Wikipedia is available under the GNU Free Documentation License.