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Homosynaptic interactions are events that occur at the junctions (synapses) where neurons meet. Homosynaptic events occur at a single synapse or group of synapses but do not involve interactions between synapses or groups of synapses. This term is often used in relation to long-term depression and long-term potentiation of neuronal firing. For example, homosynaptic long-term potentiation has been observed to occur at the synapses that connect two neurons as a result of their firing being correlated in time.

There can be four changes at synapse:

1. Synaptic depression 2. Synaptic facilitation 3. Long-term potentiation 4. Post-tetanic potentiation

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