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Homatropine

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Homatropine chemical structure
Homatropine

(N,N-dimethyl-8-azoniabicyclo[3.2.1]oct-3-yl) 2-hydroxy-2-phenyl-acetate bromide
IUPAC name
CAS number
80-49-9
ATC code

A02BX03 .

PubChem
6646
DrugBank
APRD01017
Chemical formula {{{chemical_formula}}}
Molecular weight 356.26 g/mol
Bioavailability
Metabolism
Elimination half-life
Excretion {{{excretion}}}
Pregnancy category
Legal status
Routes of administration


Main article: Alkoloids

Homatropine (Equipin, Isopto Homatropine) is an anticholinergic medication that inhibits muscarinic acetylcholine receptors and thus the parasympathetic nervous system. It is used in eye drops as a cycloplegic, to temporarily paralyze accommodation, and as a mydriatic, to dilate the pupil.

Homatropine is less potent than atropine and has a shorter duration of action. It is available as the hydrobromide or methylbromide salt. The latter, in addition to papaverine, is used as component of mild drugs that help "flush" the bile (e.g. Neo-Bilagit).

Certain preparations of drugs such as hydrocodone are mixed with a small, sub-therapeutic amount homatropine methylbromide to discourage intentional overdose. [1]

Homatropine is also given as an atropine substitute given to reverse the muscarinic and CNS effects associated with indirect cholinomimetic (anti-AChase) administration.

Side effectsEdit

ContraindicationsEdit

ReferencesEdit



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