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Hereditary motor and sensory neuropathy
OMIM [1]
DiseasesDB [2]
MedlinePlus [3]
eMedicine neuro/468
MeSH {{{MeshNumber}}}

Hereditary motor and sensory neuropathies (HMSN) are a group of neuropathies which are characterized by their impact upon both afferent and efferent neural communication.

They are more common than hereditary sensory and autonomic neuropathies.[1]


In 1968, it was classified from groups I to VII:[2][3]

Type Name Diseases Database OMIM
I Charcot-Marie-Tooth disease 1 5815 118220, 118200
II Charcot-Marie-Tooth disease 2 2343 118210, 600882
III Dejerine Sottas syndrome 5821 145900
IV Refsum's disease 11213 266500
V HMSN+hereditary spastic paraplegia - 600361
VI HMSN+hereditary optic atrophy 32095 601152
VII HMSN+retinitis pigmentosa 32094 -

HMSN is sometimes equated with Charcot-Marie-Tooth disease.[4][5]

See alsoEdit


  1. Houlden H, Blake J, Reilly MM (October 2004). Hereditary sensory neuropathies. Curr. Opin. Neurol. 17 (5): 569–77.
  2. eMedicine - Charcot-Marie-Tooth and Other Hereditary Motor and Sensory Neuropathies : Article by Aamir Hashmat.
  3. Dyck PJ, Lambert EH (June 1968). Lower motor and primary sensory neuron diseases with peroneal muscular atrophy. I. Neurologic, genetic, and electrophysiologic findings in hereditary polyneuropathies. Arch. Neurol. 18 (6): 603–18.
  4. Horacek O, Mazanec R, Morris CE, Kobesova A (October 2007). Spinal deformities in hereditary motor and sensory neuropathy: a retrospective qualitative, quantitative, genotypical, and familial analysis of 175 patients. Spine 32 (22): 2502–8.
  5. Bertorini T, Narayanaswami P, Rashed H (November 2004). Charcot-Marie-Tooth disease (hereditary motor sensory neuropathies) and hereditary sensory and autonomic neuropathies. Neurologist 10 (6): 327–37.

Further readingEdit

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