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Several factors can lead to significant cognitive impairment, particularly if they occur during pregnancy and childhood when the brain is growing and the blood-brain barrier is less effective. Such impairment may sometimes be permanent, sometimes be partially or wholly compensated for by later growth. Several harmful factors may also combine, possibly causing greater impairment.
Developed nations have implemented several health policies regarding nutrients and toxins known to influence cognitive function. These include laws requiring micronutrient fortification of certain food products and laws establishing safe levels of pollutants (e.g. lead, mercury, and organochlorides). Comprehensive policy recommendations targeting reduction of cognitive impairment in children have been proposed.
Improvements in nutrition, and in public policy in general, have been implicated in worldwide IQ increases (the Flynn effect).
Malnutrition may occur during several different periods of growth, such as pregnancy, during breastfeeding, infancy, or childhood. It may also happen due to deficiencies of different nutrients, such as micronutrients, protein or energy. This may cause different effects.
Although some observers have argued that the first six months of life are the most critical in the sense that malnutrition during that time period harms cognitive development more than malnutrition later in life, a study from the Philippines argue that malnutrition in the second year of life may have a larger negative impact than malnutrition in the first year of life.
Intrauterine growth retardation
Undernutrition during pregnacy, and other factors, may cause intrauterine growth retardation (IUGR), which is one cause of low birth weight. However, it has been suggested that in IUGR the brain may be selectively spared. Brain growth is usually less affected than whole body weight or length. Several studies from developed nations have found that with the exception of extreme intrauterine growth retardation also affecting brain growth, and hypoxic injury, IUGR seems to have little or no measurable effect on mental performance and behavior in adolescence or adulthood. For example, acute undernutrition for a few months during the dutch famine of 1944 caused a decrease in mean birthweigh in certain areas. This was not later associated with a change in performance on IQ tests for 18-19 years old Dutch males draftees from these areas compared to control areas. The subjects were exposed to famine prenatally but not after birth. During the famine, births decreased more among those with lower SES, whereas after the famine, there was a compensatory increase in births among the those with lower SES. Since SES correlates with IQ, this may have hidden an effect caused by the undernutrition.
The longstanding belief that breastfeeding correlates with an increase in the IQ of offspring was challenged in a 2006 paper published in the British Medical Journal. The results indicated that mother's IQ, not breastfeeding, explained the differences in the IQ scores of offspring. The results of this study argued that prior studies had not allowed for the mother's IQ. Since mother's IQ was predictive of whether a child was breastfed, the study concluded that "breast feeding [itself] has little or no effect on intelligence in children." Instead, it was the mother's IQ that had a significant correlation with the IQ of her offspring, whether the offspring was breastfed or was not breastfed. The study has been subject to various criticisms. Another study found a positive effect of breastfeeding also after controlling for parental IQ.
Two studies in Chile on 18 years old high-school graduates found that nutritional status during the first year of life affected IQ, scholastic achievement, and brain volume.
Micronutrient deficiencies (e.g. in iodine and iron) influence the development of intelligence and remain a problem in the developing world. Policy recommendations to increase availability of micronutrient supplements have been made and justified in part by the potential to counteract intelligence-related developmental problems. For example, the Copenhagen consensus, states that lack of both iodine and iron has been implicated in impaired brain development, and this can affect enormous numbers of people: it is estimated that 2 billion people (one-third of the total global population) are affected by iodine deficiency, including 285 million 6- to 12-year-old children. In developing countries, it is estimated that 40% of children aged 4 and under suffer from anaemia because of insufficient iron in their diets.  A joint statement on vitamin and mineral deficiencies says that the severity of such deficiencies "means the impairment of hundreds of millions of growing minds and the lowering of national IQs."
Overall, studies investigating whether cognitive function in already iron-deficient children can be improved with iron supplements have produced mixed results, possible becaue deficiency in critical growth periods may cause irreversible damage. However, several studies with better design have shown substantial benefits. In order to prevent iron deficiency an option is giving specific supplementation, for example as tablets. However, this is costly, distribution mechanisms are often ineffective, and compliance is low. Fortification of staple foods (cereals, flour, sugar, salt) to deliver micronutrients to children on a large scale is probably the most sustainable and affordable option, even though commitment from governments and the food industry is needed. Developed nations fortify several foods with various micronutrients.
Additional vitamin-mineral supplementation may have an effect also in the developed world. A study giving such supplementation to "working class," primarily Hispanic, 6-12 years old children in the United States for 3 months found an average increase 2 to 3 IQ points. Most of this can explaind by the very large increase for a subgroup of the children, presumably because these were not adequately nourished unlike the majority. The study suggests that parents of schoolchildren whose academic performance is substandard would be well advised to seek a nutritionally oriented physician for assessment of their children's nutritional status as a possible etiology.
More speculatively, other nutrients may prove important in the future. Fish oil supplement to pregnant and lactating mothers has been linked to increased cognitive ability in one study. Vitamin B12 and folate may be important for cognitive function in old age.
Protein and energy malnutition
One study from developing country, Guatemala, found that poor growth during infancy, rather than low birth weight, was negatively related to adolescent performance on cognitive and achievement tests. A later related very long term study looked at the effect of giving 6-24 months old children in Guatemala a high protein-energy drink as a dietary supplement. A significantly positive and fairly substantial effects was found on increasing the probability of attending school and of passing the first grade, increasing the grade attained by age 13, increasing completed schooling attainment, and for adults aged 25-40 increasing IQ test scores.
31% of children under the age of 5 in the developing world are moderately (height-for-age is below minus 2 standard deviations) or severly stunted (below minus 3 standard deviations). The prevalence was even higher previously since the worldwide prevalence of stunting is declining by about half of a percentage point each year. A study on stunted children aged 9-24 months in Jamica found that when aged 17-18 years they had significantly poorer scores than a non-stunted group on cognitive and educational tests and psychosocial functioning. Giving a nutritional supplementation (1 kg milk based formula each week) to these already stunted children had no significant effect on later scores, but psychosocial stimulation (weekly play sessions with mother and child) had a positive effect.
Certain toxins, such as lead, mercury, arsenic, toluene, and PCB are well-known causes of neuro-developmental disorders. Recognition of these risks has led to evidence-based programmes of prevention, such as elimination of lead additives in petrol. Although these prevention campaigns are highly successful, most were initiated only after substantial delays.
Policies to manage lead differ between nations, particularly between the developed and developing world. Use of leaded gasoline has been reduced or eliminated in most developed nations, and lead levels in US children have been substantially reduced by policies relating to lead reduction. Even slightly elevated lead levels around the age of 24 months are associated with intellectual and academic performance deficits at age 10 years.
A Lancet review identified 201 chemicals with the ability to cause clinical neurotoxic effects in human adults, as described in the peer-reviewed scientific literature. Most of them are commonly used. Many additional chemicals have been shown to be neurotoxic in laboratory models. The article notes that children are more vulnerable and argues that new, precautionary approaches that recognise the unique vulnerability of the developing brain are needed for testing and control of chemicals in order to avoid the previous substantial before starting restrictions on usage. An appendix listed furher industrial chemicals considered to be neurotoxic.
Current cannabis use was found to be significantly correlated in a dose-dependent manner with a decline in IQ scores. However, no such decline was seen in subjects who had formerly been heavy cannabis users and had stopped taking the drug. The authors concluded that cannabis does not have a long-term effect on intelligence. Effects on foetal development are minimal when compared with the well-documented adverse effects of tobacco or alcohol use.
Maternal tobacco smoking during pregnancy is associated with increased activity, decreased attention, and diminished intellectual abilities. However, a recent study finds that maternal tobacco smoking has no direct causal effect on the child's IQ. Adjusting for maternal cognitive ability as measured by IQ and education eliminated the association between lower IQ and tobacco smoking. But another study instead looking at the relationship between environmental tobacco smoke exposure, measured with a blood biomarker, and cognitive abilities among U.S. children and adolescents 6–16 years of age, found an inverse association between exposure and cognitive deficits among children even at extremely low levels of exposure. The study controlled for sex, race, region, poverty, parent education and marital status, ferritin, and blood lead concentration.
Healthcare during pregnancy and childbirth
Healthcare during pregnancy and childbirth, access to which is often governed by policy, also influences cognitive development. Preventable causes of low intelligence in children include infectious diseases such as meningitis, parasites, and cerebral malaria, prenatal drug and alcohol exposure, newborn asphyxia, low birth weight, head injuries, and endocrine disorders. A direct policy focus on determinants of childhood cognitive ability has been urged.
A recent theory suggests that early childhood stress may affect the developing brain and cause negative effects.
Tropical infectious diseases
On the disease front, malaria affects 300–500 million persons each year, mostly children under the age of 5 in Africa, causing widespread anemia during a period of rapid brain development and also direct brain damage from cerebral malaria to which children are more vulnerable. Policies aimed at malaria reduction may have cognitive benefits. It has been suggested that the future economic and educational development of Africa critically depends on the eradication of malaria.
Association with other diseases
There are numerous diseases affecting the central nervous system which can cause cognitive impairment. Many of these are associated with aging. Some common examples include Alzheimer's disease and Multi-infarct dementia. Many diseases may be neurological or psychiatric and may primarily affect brain. Others may affect many other organs, like HIV, Hashimoto's thyroiditis causing hypothyroidism, or cancer.
Persons with a higher IQ have generally lower adult morbidity and mortality. This may be because they better avoid injury and take better care of their own health, or alternatively may be due to a slight increased propensity for material wealth. Post-Traumatic Stress Disorder, severe depression, and schizophrenia are less prevalent in higher IQ bands. The Archive of General Psychiatry published a longitudinal study of a randomly selected sample of 713 study participants (336 boys and 377 girls), from both urban and suburban settings. Of that group, nearly 76 percent had suffered through at least one traumatic event. Those participants were assessed at age 6 years and followed up to age 17 years. In that group of children, those with an IQ above 115 were significantly less likely to have Post-Traumatic Stress Disorder as a result of the trauma, less likely to display behavioral problems, and less likely to experience a trauma. The low incidence of Post-Traumatic Stress Disorder among children with higher IQs was true even if the child grew up in an urban environment (where trauma averaged three times the rate of the suburb), or had behavioral problems. On the other hand, higher IQ shows a higher prevalence of those conditioned with Obsessive Compulsive Disorder.
Major depression, affecting about 16% of the population on at least one occasion in their lives and the leading cause of disability in North America, may give symptoms similar to dementia. Patients treated for depression score higher on IQ tests than before treatment.
Research in Scotland has shown that a 15-point lower IQ meant people had a fifth less chance of seeing their 76th birthday, while those with a 30-point disadvantage were 37% less likely than those with a higher IQ to live that long. In addition, a study of 11,282 individuals in Scotland who took intelligence tests at ages 7, 9 and 11 in the 1950s and 1960s, found an "inverse linear association" between childhood intelligence and hospital admissions for injuries in adulthood. The association between childhood IQ and the risk of later injury remained even after accounting for factors such as the child's socioeconomic background.
A decrease in IQ has also been shown as an early predictor of late-onset Alzheimer's Disease and other forms of dementia. In a 2004 study, Cervilla and colleagues showed that tests of cognitive ability provide useful predictive information up to a decade before the onset of dementia.
However, when diagnosing individuals with a higher level of cognitive ability, in this study those with IQ's of 120 or more, patients should not be diagnosed from the standard norm but from an adjusted high-IQ norm that measured changes against the individual's higher ability level.
In 2000, Whalley and colleagues published a paper in the journal Neurology, which examined links between childhood mental ability and late-onset dementia. The study showed that mental ability scores were significantly lower in children who eventually developed late-onset dementia when compared with other children tested.
- ↑ 1.0 1.1 Olness, K. "Effects on brain development leading to cognitive impairment: a worldwide epidemic," Journal of Developmental and Behavioral Pediatrics 24, no. 2 (2003): 120–30.
- ↑ The Impact of Early Childhood Nutritional Status on Cognitive Development: Does the Timing of Malnutrition Matter? Paul Glewwe and Elizabeth M. King THE WORLD BANK ECONOMIC REVIEW, VOL. 15, NO. 1, 81-113
- ↑ Causes and Consequences of Intrauterine Growth Retardation European Journal of CLINICAL NUTRITION Volume 52, Supplement 1, January 1998.Neisser et al.. Intelligence: Knowns and Unknowns. Board of Scientific Affairs of the American Psychological Association.
- ↑ Geoff Der, G David Batty, Ian J. Deary. Effect of breast feeding on intelligence in children: prospective study, sibling pairs analysis, and meta-analysis. (Abstract) British Medical Journal.
- ↑ Rapid Responses
- ↑ Influence of breast-feeding and parental intelligence on cognitive development in the 24-month-old child. Clin Pediatr (Phila). 2004 Oct;43(8):753-61. Influence of breast-feeding and parental intelligence on cognitive development in the 24-month-old Gomez-Sanchiz M, Canete R, Rodero I, Baeza JE, Gonzalez JA.
- ↑ D.M. Ivanovic et al., "Nutritional status, brain development and scholastic achievement of Chilean high-school graduates from high and low intellectual quotient and socio-economic status," British Journal of Nutrition 87, no. 1 (January 2002): 81–92; D.M. Ivanovic et al., "Head size and intelligence, learning, nutritional status and brain development. Head, IQ, learning, nutrition and brain," Neuropsychologia 42, no. 8 (2004): 1118–31.
- ↑ Behrman, J.R., Alderman, H., and Hoddinott, J., "Hunger and Malnutrition," Copenhagen Consensus 2004.
- ↑ UNICEF and The Micronutrient Initiative, "Vitamin & Mineral Deficiency: A Global Progress Report," March 2004.
- ↑ Saloojee, H. and Pettifor, J., Iron deficiency and impaired child development," BMJ 323 (December 2001): 1377–78
- ↑ FOOD FORTIFICATION TECHNOLOGY Food Fortification: Technology and Quality Control. (FAO Food And Nutrition Paper - 60)
- ↑ The effect of vitamin-mineral supplementation on the intelligence of American schoolchildren: a randomized, double-blind placebo-controlled trial J Altern Complement Med. 2000 Feb;6(1):31-5.
- ↑ Helland IB, Smith L, Saarem K, Saugstad OD, Drevon CA. Maternal supplementation with very-long-chain n-3 fatty acids during pregnancy and lactation augments children's IQ at 4 years of age. Pediatrics. 2003 Jan;111(1):e39-44.
- ↑ Duthie SJ, Whalley LJ, Collins AR, Leaper S, Berger K, Deary IJ. Homocysteine, B vitamin status, and cognitive function in the elderly. Am J Clin Nutr. 2002 May;75(5):908-13. Erratum in: Am J Clin Nutr. 2003 Feb;77(2):523.
- ↑ Pollitt E, Gorman KS, Engle P, Martorell R and Rivera JA, 1993. Early Supplementary Feeding and Cognition: Effects Over Two Decades Monographs of the Society for Research in Child Development, Serial No. 235, 58(7): 122 pages.
- ↑ Schooling, educational achievement, and cognitive functioning among young Guatemalan adults. Food Nutr Bull. 2005 Jun;26(2 Suppl 1):S46-54. Stein AD, Behrman JR, DiGirolamo A, Grajeda R, Martorell R, Quisumbing A, Ramakrishnan U.
- ↑ 
- ↑ Stunted growth affects almost 40 percent of the developing world's infants, Cornell study reports
- ↑ Effects of early childhood psychosocial stimulation and nutritional supplementation on cognition and education in growth-stunted Jamaican children: prospective cohort study Lancet (British edition), 2005 (Vol. 966) (No. 9499) 1804-1807. Walker, S. P., Chang, S. M., Powell, C. A., Grantham-McGregor, S. M.
- ↑ Effects of psychosocial stimulation and dietary supplementation in early childhood on psychosocial functioning in late adolescence: follow-up of randomised controlled trial Susan P Walker, professor1, Susan M Chang, lecturer1, Christine A Powell, senior lecturer1, Emily Simonoff, professor2, Sally M Grantham-McGregor, professor3. BMJ 2006;333:472 (2 September), doi:10.1136/bmj.38897.555208.2F (published 28 July 2006)
- ↑ Developmental neurotoxicity of industrial chemicals. Lancet. 2006 Dec 16;368(9553):2167-78. Grandjean P, Landrigan PJ.
- ↑ Meyer, P.A., McGeehin, M.A., and Falk, H. "A global approach to childhood lead poisoning prevention," International Journal of Hygiene and Environmental Health 206, nos. 4–5 (August 2003): 363–69.
- ↑ Low-Level Lead Exposure, Intelligence and Academic Achievement: A Long-term Follow-up Study David C. Bellinger PhD, MSc1, Karen M. Stiles PhD, MN1, and Herbert L. Needleman MD1. PEDIATRICS Vol. 90 No. 6 December 1992, pp. 855-861
- ↑ In Utero Exposure to Background Concentrations of DDT and Cognitive Functioning among Preschoolers Núria Ribas-Fitó1, Maties Torrent2, Daniel Carrizo3, Laura Muñoz-Ortiz1, Jordi Júlvez1, Joan O. Grimalt3 and Jordi Sunyer1 American Journal of Epidemiology 2006 164(10):955-962
- ↑ Developmental neurotoxicity of industrial chemicals. Lancet. 2006 Dec 16;368(9553):2167-78. Grandjean P, Landrigan PJ.
- ↑ Potentials for exposure to industrial chemicals suspected of causing developmental neurotoxicity Philippe Grandjean, MD, PhD, Adjunct Professor Marian Perez, MPH, Project Coordinator Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
- ↑ Long-term effects of exposure to cannabis. Iversen L. Curr Opin Pharmacol. 2005 Feb;5(1):69-72.
- ↑ Abel, E.L., & Sokel, R.J. (1987). Incidence of fetal alcohol syndrome and economic impact of FAS-related anomalies: Drug alcohol syndrome and economic impact of FAS-related anomalies. Drug and Alcohol Dependency, 19(1), 51-70.
- ↑ The effects of tobacco exposure on children's behavioral and cognitive functioning: implications for clinical and public health policy and future research. Weitzman M, Byrd RS, Aligne CA, Moss M. Neurotoxicol Teratol. 2002 May-Jun;24(3):397-406.
- ↑ Maternal smoking during pregnancy and offspring IQ Naomi Breslau1,*, Nigel Paneth1, Victoria C Lucia1 and Rachel Paneth-Pollak2 International Journal of Epidemiology 2005 34(5):1047-1053
- ↑ Exposure to Environmental Tobacco Smoke and Cognitive Abilities among U.S. Children and Adolescents Kimberly Yolton, Kim Dietrich, Peggy Auinger, Bruce P. Lanphear, and Richard Hornung1. Environ Health Perspect. 2005 January; 113(1): 98–103.
- ↑ How similar are fluid cognition and general intelligence? A developmental neuroscience perspective on fluid cognition as an aspect of human cognitive ability, Behavioral and Brain Sciences (2006), 29: 109-125 Cambridge University Press, Clancy Blair. Multiple comments can be seen on Google Scholar.
- ↑ Boivin, M.J., "Effects of early cerebral malaria on cognitive ability in Senegalese children," Journal of Developmental and Behavioral Pediatrics 23, no. 5 (October 2002): 353–64. Holding, P.A. and Snow, R.W., "Impact of Plasmodium falciparum malaria on performance and learning: review of the evidence," American Journal of Tropical Medicine and Hygiene 64, suppl. nos. 1–2 (January–February 2001): 68–75.
- ↑ "Stupidity or worms": do intestinal worms impair mental performance? Watkins WE, Pollitt E. Psychol Bull. 1997 Mar;121(2):171-91
- ↑ Naomi Breslau, PhD; Victoria C. Lucia, PhD; German F. Alvarado, MD, MPH. Intelligence and Other Predisposing Factors in Exposure to Trauma and Posttraumatic Stress Disorder. A Follow-up Study at Age 17 Years. Arch Gen Psychiatry. 2006;63:1238-1245.
- ↑ GT_DM_5b.pdf. (PDF)
- ↑ Effects of major depression on estimates of intelligence Sackeim HA, Freeman J, McElhiney M, Coleman E, Prudic J, Devanand DP. J Clin Exp Neuropsychol. 1992 Mar;14(2):268-88.
- ↑ Improvement of cognitive functioning in mood disorder patients with depressive symptomatic recovery during treatment: An exploratory analysis LAURA MANDELLI, Psy. D, ALESSANDRO SERRETTI, md,1 CRISTINA COLOMBO, md, MARCELLO FLORITA, Psy. D, ALESSIA SANTORO, Psy. D, DAVID ROSSINI, MD, RAFFAELLA ZANARDI, MD AND ENRICO SMERALDI, MD. Psychiatry and Clinical Neurosciences Volume 60 Issue 5 Page 598 - October 2006
- ↑ Whalley and Deary. Longitudinal cohort study of childhood IQ and survival up to age 76. British Medical Journal 2001, 322:819-819.
- ↑ Debbie A. Lawlor, University of Bristol, Heather Clark, University of Aberdeen, David A. Leon, London School of Hygiene & Tropical Medicine. Associations Between Childhood Intelligence and Hospital Admissions for Unintentional Injuries in Adulthood: The Aberdeen Children of the 1950s Cohort Study. American Journal of Public Health, December 2006.
- ↑ Cervilla et al. Premorbid cognitive testing predicts the onset of dementia and Alzheimer's disease better than and independently of APOE genotype. Psychiatry 2004;75:1100-1106..
- ↑ Dorene Rentz, Brigham and Women's Hospital's Department of Neurology and Harvard Medical School. More Sensitive Test Norms Better Predict Who Might Develop Alzheimer's Disease. Neuropsychology, published by the American Psychological Association.
- ↑ Whalley et al.. Childhood mental ability and dementia. Neurology 2000;55:1455-1459..
- Sungthong, R., Mo-suwan, L., and Chongsuvivatwong, V., "Effects of haemoglobin and serum ferritin on cognitive function in school children," Asia Pacific Journal of Clinical Nutrition 11, no. 2 (2002): 117–22
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