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Chemical name 2-[4-(ethylthio)-2,5-dimethoxyphenyl]ethanaminol
Chemical formula C12H19NO3S
CAS number 207740-38-3
Molecular mass  ?
Melting point 122 °C

HOT-2, or 2,5-dimethoxy-4-(β-ethylthio)-N-hydroxyphenethylamine is a psychedelic phenethylamine of the 2C family. It was presumably first synthesized by Alexander Shulgin and reported in his book PIHKAL.


HOT-2's full chemical name is 2-[4-(2-ethylthio)-2,5-dimethoxyphenyl-N-hydroxyethanamine. It has structural properties similar to 2C-T-2 and to other drugs in the HOT- series, with the most closely related compounds being HOT-7 and HOT-17.

General InformationEdit

The dosage range of HOT-2 is typically 10-18 mg and its duration is approximately 6-10 hours according to Shulgin. HOT-2 produces visuals and moving, flowing lights. It also causes euphoria and increases blood pressure.



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