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Guanylate cyclase

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Guanylate cyclase (EC, also known as guanylyl cyclase or GC) is a lyase enzyme.


It catalyzes the conversion of guanosine triphosphate (GTP) to 3',5'-cyclic guanosine monophosphate (cGMP) and pyrophosphate:


There are soluble and membrane-bound forms of guanylyl cyclases.


Once formed, cGMP can be degraded by phosphodiesterases, which themselves are under different forms of regulation, depending on the tissue.

Like cAMP, cGMP is known to regulate many cellular proteins, such as protein kinases, ion channels, and phosphodiesterases.

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{{enWP| Guanylate cyclase]]

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