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The G_s alpha subunit (or Gs protein) is a heterotrimeric G protein subunit which activates adenylate cyclase. Researchers have discovered that a change in the location of this protein in the brain could serve as a biomarker for depression, allowing a simple, rapid, laboratory test to identify patients with depression. ^[1]

ReceptorsEdit

The G-protein coupled receptors that couple to this kind of G-protein are for example:

• 5-HT receptors type 4 and 7
• D1-like dopamine receptors
• β-adrenergic receptors
• M1 receptor (primarily G_q-coupled)
• Prostaglandin D2 receptor
• Adenosine receptor A2a and A2b
• Calcitonin receptor
• Calcitonin gene-related peptide receptor

FunctionEdit

Main article: function of cAMP-dependent protein kinase

The general function of G_s is to activate adenylate cyclase, which, in turn, produces cAMP, which, in turn activates cAMP-dependent protein kinase. Further effects of G_s is thus found in function of cAMP-dependent protein kinase.

See alsoEdit

• Second messenger system

ReferencesEdit

External linksEdit

• MeSH G(s)alpha
• MeSH GNAS+protein,+human

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