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Changes: Gs alpha subunit

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(New page: {{BioPsy}} {{protein |Name=GNAS complex locus |caption= |image= |width= |HGNCid=4392 |Symbol=GNAS |AltSymbols=GNAS1 |EntrezGene=2778 |OMIM=139320 |RefSeq=NM_000516 |UniProt=Q5JWF2 |PDB= |E...)
 
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Latest revision as of 21:25, November 16, 2010

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GNAS complex locus
Symbol(s): GNAS GNAS1
Locus: 20 q13.2 -13.3
EC number [1]
EntrezGene 2778
OMIM 139320
RefSeq NM_000516
UniProt Q5JWF2

The Gs alpha subunit (or Gs protein) is a heterotrimeric G protein subunit which activates adenylate cyclase. Researchers have discovered that a change in the location of this protein in the brain could serve as a biomarker for depression, allowing a simple, rapid, laboratory test to identify patients with depression. [1]


ReceptorsEdit

The G-protein coupled receptors that couple to this kind of G-protein are for example:

FunctionEdit

Main article: function of cAMP-dependent protein kinase

The general function of Gs is to activate adenylate cyclase, which, in turn, produces cAMP, which, in turn activates cAMP-dependent protein kinase. Further effects of Gs is thus found in function of cAMP-dependent protein kinase.

See alsoEdit

ReferencesEdit

External linksEdit


Template:GTPases



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