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Individual differences |
Methods | Statistics | Clinical | Educational | Industrial | Professional items | World psychology |
Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)
|GNAS complex locus|
|Locus:||20 q13.2 -13.3|
The Gs alpha subunit (or Gs protein) is a heterotrimeric G protein subunit which activates adenylate cyclase. Researchers have discovered that a change in the location of this protein in the brain could serve as a biomarker for depression, allowing a simple, rapid, laboratory test to identify patients with depression. 
The G-protein coupled receptors that couple to this kind of G-protein are for example:
- 5-HT receptors type 4 and 7
- D1-like dopamine receptors
- β-adrenergic receptors
- M1 receptor (primarily Gq-coupled)
- Prostaglandin D2 receptor
- Adenosine receptor A2a and A2b
- Calcitonin receptor
- Calcitonin gene-related peptide receptor
- Main article: function of cAMP-dependent protein kinase
The general function of Gs is to activate adenylate cyclase, which, in turn, produces cAMP, which, in turn activates cAMP-dependent protein kinase. Further effects of Gs is thus found in function of cAMP-dependent protein kinase.
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