Gs alpha subunit

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GNAS complex locus
Symbol(s):	GNAS GNAS1
Locus:	20 q13.2 -13.3
EC number	[1]
EntrezGene	2778
OMIM	139320
RefSeq	NM_000516
UniProt	Q5JWF2

The G_s alpha subunit (or Gs protein) is a heterotrimeric G protein subunit which activates adenylate cyclase. Researchers have discovered that a change in the location of this protein in the brain could serve as a biomarker for depression, allowing a simple, rapid, laboratory test to identify patients with depression. ^[1]

Contents 1 Receptors 2 Function 3 See also 4 References 5 External links

[edit] Receptors

The G-protein coupled receptors that couple to this kind of G-protein are for example:

• 5-HT receptors type 4 and 7
• D1-like dopamine receptors
• β-adrenergic receptors
• M1 receptor (primarily G_q-coupled)
• Prostaglandin D2 receptor
• Adenosine receptor A2a and A2b
• Calcitonin receptor
• Calcitonin gene-related peptide receptor

[edit] Function

Main article: function of cAMP-dependent protein kinase

The general function of G_s is to activate adenylate cyclase, which, in turn, produces cAMP, which, in turn activates cAMP-dependent protein kinase. Further effects of G_s is thus found in function of cAMP-dependent protein kinase.

[edit] See also

• Second messenger system

[edit] References

[edit] External links

• MeSH G(s)alpha
• MeSH GNAS+protein,+human

Template:GTPases

This page uses content from the English-language version of Wikipedia. The original article was at Gs alpha subunit. The list of authors can be seen in the page history. As with Psychology Wiki, the text of Wikipedia is available under the GNU Free Documentation License.