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GNAS complex locus
Symbol(s): GNAS GNAS1
Locus: 20 q13.2 -13.3
EC number [1]
EntrezGene 2778
OMIM 139320
RefSeq NM_000516
UniProt Q5JWF2

The Gs alpha subunit (or Gs protein) is a heterotrimeric G protein subunit which activates adenylate cyclase. Researchers have discovered that a change in the location of this protein in the brain could serve as a biomarker for depression, allowing a simple, rapid, laboratory test to identify patients with depression. [1]


The G-protein coupled receptors that couple to this kind of G-protein are for example:


Main article: function of cAMP-dependent protein kinase

The general function of Gs is to activate adenylate cyclase, which, in turn, produces cAMP, which, in turn activates cAMP-dependent protein kinase. Further effects of Gs is thus found in function of cAMP-dependent protein kinase.

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