Gonadotropin-releasing hormone receptor
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| Gonadotropin-releasing hormone receptor | |
|---|---|
| Symbol(s): | GNRHR GnRH-R; LRHR; |
| Locus: | 4 q21.2 |
| EC number | [1] |
| EntrezGene | 2798 |
| OMIM | 138850 |
| RefSeq | NM_000406 |
| UniProt | P30968 |
Gonadotropin-releasing hormone receptor (GNRHR) is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate.
Contents |
[edit] Function
Following binding of Gonadotropin releasing hormone (GNRH), GNRHR associates with G-proteins that activate a phosphatidylinositol (PtdIns)-calcium second messenger system. Activation of GNRHR ultimately causes the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH).
[edit] Gene
Alternative splicing of the GNRHR gene, GNRHR, results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for GNRHR.
[edit] Regulation
The GNRHR responds to GNRH as well as to GNRH agonists. Agonists stimulate the receptor, however prolonged exposure leads to a downregulation effect resulting in hypogonadism, an effect that is often medically utilized. GNRH antagonists block the receptor and inhibit gonadotropin release. GNRHRs are further regulated by the presence of sex hormones, inhibin, and activin.
[edit] Clinical implications
Defects in the GNRHR are a cause of hypogonadotropic hypogonadism (HH).
| This page uses content from the English-language version of Wikipedia. The original article was at Gonadotropin-releasing hormone receptor. The list of authors can be seen in the page history. As with Psychology Wiki, the text of Wikipedia is available under the GNU Free Documentation License. |
