Golgi cell
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| Golgi cell | ||
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| Microcircuitry of the cerebellum. Excitatory synapses are denoted by (+) and inhibitory synapses by (-). MF: Mossy fiber. DCN: Deep cerebellar nuclei. IO: Inferior olive. CF: Climbing fiber. GC: Granule cell. PF: Parallel fiber. PC: Purkinje cell. GgC: Golgi cell. SC: Stellate cell. BC: Basket cell. | ||
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In neuroscience, Golgi cells are inhibitory interneurons found within the granular layer of the cerebellum. These cells synapse onto the soma of granule cells and unipolar brush cells. They receive excitatory input from mossy fibres, also synapsing on granule cells, and parallel fibers, which are long granule cell axons. Thereby this circuitry allows for feed-forward and feed-back inhibition of granule cells.
The main synapse made by these cells is a synapse onto the mossy fibre - granule cell excitatory synapse in a glomerulus. The glomerulus is made up of the mossy fibre terminal, granule cell dendrites, the golgi terminal and is enclosed by a glial coat. (Jakob and Hamori, 1988) The golgi cell acts by altering the mossy fibre - granule cell synapse.
The golgi cells use GABA as their transmitter. The basal level of GABA produces a postsynaptic leak conductance by tonically activating alpha 6-containing GABA-A receptors on the granule cell (Brickley et al., 1996; Tia et al., 1996; Wall and Usowicz, 1997). These high-affinity receptors are located both synaptically and extrasynaptically on the granule cell. The synaptic receptors mediate phasic contraction, duration of around 20-30ms whereas the extrasynapatic receptors mediate tonic inhibiton of around 200ms, and are activated by synapse spill over. (Nusser et al., 1998)
Additionally the GABA acts on GABA-B receptors which are located presynaptically on the mossy fibre terminal. These inhibit the mossy fibre evoked EPSCs of the granule cell in a temperature and frequency dependent manner. At high mossy firing frequency (10Hz) there is no effect of GABA acting on presynaptic GABA-B receptors on evoked EPSCs. However, at low (1Hz) firing the GABA does have an effect on the EPSCs mediated via these presynaptic GABA-B receptors.
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! Myelencephalon/
medulla
| colspan="1" style="text-align:left;width:100%;font-size:95%;background:#f7f7f7;" | {| class="navbox collapsible nowraplinks" style="margin:auto; background:white;background:white;"
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!| colspan="1" style="text-align:left;width:100%;font-size:95%;" | surface: Posterior median sulcus - Postero-lateral sulcus - Area postrema
cranial nuclei: GVA: VII,IX,X: Solitary/tract • SVA: Gustatory nucleus • GSE: XII • GVE: IX,X,XI: Ambiguus • SVE: X: Dorsal • IX: Inferior salivatory nucleus - MLF, III, IV and VI
sensory/ascending: Gracile nucleus • Cuneate nucleus (Accessory cuneate nucleus) • Sensory decussation • Medial lemniscus
motor/descending: Dorsal respiratory group
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| colspan="1" style="text-align:left;width:100%;font-size:95%;background:#f7f7f7;" | motor/descending: Ventral respiratory group - Pyramid (Motor decussation) - Inferior olivary nucleus (Olivocerebellar tract, Rubro-olivary tract)
surface: Anterior median fissure - Antero-lateral sulcus - Arcuate nucleus of medulla - Olivary body
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| colspan="1" style="text-align:left;width:100%;font-size:95%;" | Reticular formation (Gigantocellular, Parvocellular, Ventral, Lateral, Paramedian) • Raphe nuclei (Obscurus, Magnus, Pallidus) |} |}
| This page uses content from the English-language version of Wikipedia. The original article was at Golgi cell. The list of authors can be seen in the page history. As with Psychology Wiki, the text of Wikipedia is available under the GNU Free Documentation License. |
