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Individual differences |
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Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)
Activation and inactivationEdit
Arrangement of subunitsEdit
Strychnine-sensitive glycine receptors are members of a family of Ligand-gated ion channels. Receptors of this family are arranged as five subunits surrounding a central pore, with each subunit composed of four α helical transmembrane segments.
The adult form of the GlyR is the heteromeric α1β receptor, which is believed to have a stoichiometry (proportion) of three α1 subunits and two β subunits  or four α1 subunits and one β subunit. The α-subunits are also able to form functional homo-pentameric receptors in heterologous expression systems in African clawed frog's oocytes or mammalian cell lines, and the α1 homomeric receptor is essential for studies of channel pharmacokinetics and pharmacodynamics.
- ↑ Rajendra, S, Lynch JW, Schofield PR (1997). The glycine receptor. Pharmacology and Therapeutics 73 (2): 121-146. PMID 9131721.
- ↑ Miyazawa, A, Fujiyoshi Y, Unwin N (2003). Structure and gating mechanism of the acetylcholine receptor pore. Nature 423 (6943): 949-955. PMID 12827192.
- ↑ Kuhse, J, Laube B, Magalei D, Betz H (1993). Assembly of the inhibitory glycine receptor: identification of amino acid sequence motifs governing subunit stoichiometry. Neuron 11 (6): 1049-1056. PMID 8274276.
- ↑ 4.0 4.1 Kuhse, J, Betz H, Kirsch J (1995). The inhibitory glycine receptor: architecture, synaptic localization and molecular pathology of a postsynaptic ion-channel complex. Current Opinion in Neurobiology 5 (3): 318-323. PMID 7580154.
- ↑ Lewis, TM, Schofield PR, McClellan AM (2003). Kinetic determinants of agonist action at the recombinant human glycine receptor. Journal of Physiology 549 (Part 2): 361-374. PMID 12679369.
- ↑ OMIM - STIFF-PERSON SYNDROME; SPS. URL accessed on 2007-06-20.
- ↑ Dahan M, Lévi S, Luccardini C, Rostaing P, Riveau B, Triller A (2003). Diffusion dynamics of glycine receptors revealed by single-quantum dot tracking. Science 302 (5644): 442–5.
Ion channel, receptor: ligand-gated ion channels
5-HT receptor (5-HT3 serotonin receptor (A)) - GABA receptor (GABA A (α1, α2, α3, α4, α5, α6, β1, β2, β3, γ2, γ3, ε), GABA C (ρ1, ρ2)) - Glycine receptor (α1, α2, β) - Nicotinic acetylcholine receptor (α1, α2, α3, α4, α5, α7, α9, β1, β2, β3, β4, δ, ε, (α4)2(β2)3, (α7)5, Ganglion type, Muscle type)
|Ionotropic glutamate receptors|
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