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|Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)|
|Symbol(s):||NR3C1 GCR, GCCR, GRL|
|Locus:||5 q31 -32|
The glucocorticoid receptor (GR) or nuclear receptor subfamily 3, group C, member 1 is a ligand-activated intracytoplasmatic transcription factor that interacts with high affinity to cortisol and other glucocorticoids.
Like the other steroid receptors the structure of the GR consists of a variable domain, the DNA-binding domain with zinc fingers, a hinge region, and the hormone-binding domain with a final carboxy terminal.
Binding and responseEdit
Cortisol diffuses through the cell wall into the cytoplasm and binds to the glucocorticoid receptor (GR) forming a GR-hormone complex. Initially the GR includes the heat shock protein 90 (hsp90), the heat shock protein 70 (hsp70) and the protein FKBP52 (FK506-binding protein 52). Dissociation of the GR complex releases the heat shock chaperones and yields the free cortisol-receptor subunits that link up as homodimers. These are translocated via nucleopores into the nucleus and bind with zinc fingers to the specific DNA responsive elements activating gene transcription. The biologic response depends on the cell type.
Agonists and antagonistsEdit
Constitutive androstane receptor - Core binding factor - E2F - Farnesoid X receptor - Kruppel-like factors - Nanog - NF-kB - Oct-4 - P300/CBP - Peroxisome proliferator-activated - PIT-1 - Rho factor - R-SMAD - Sigma factor - Sox2 - Sp1 - STAT protein
Steroid hormone receptors
Type I: Glucocorticoid receptor - Mineralocorticoid receptor - Sex hormone receptor (Androgen receptor, Estrogen receptor, Progesterone receptor)
Type II: Calcitriol receptor - Retinoid receptor (Retinoic acid receptor, Retinoid X receptor) - Thyroid hormone receptor
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