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Glucagon receptor
Symbol(s) GCGR; GGR; MGC138246
External IDs OMIM: 138033 MGI99572 Homologene131
Human Mouse Entrez 2642 14527 Ensembl na ENSMUSG00000025127 Uniprot na Q3UN81 Refseq NM_000160 (mRNA)
NP_000151 (protein)
NM_008101 (mRNA)
NP_032127 (protein)
Location na Chr 11: 120.35 - 120.36 Mb
Pubmed search [1] [2]

The glucagon receptor is a 62 kDa peptide that is activated by glucagon and is a member of the G-protein coupled family of receptors, coupled to Gs.[1] Stimulation of the receptor results in activation of adenylate cyclase and increased levels of intracellular cAMP.

Glucagon receptors are mainly expressed in liver and in kidney with lesser amounts found in heart, adipose tissue, spleen, thymus, adrenal glands, pancreas, cerebral cortex, and gastrointestinal tract.


Further readingEdit

  • Levey GS, Weiss SR, Ruiz E (1975). Characterization of the glucagon receptor in a pheochromocytoma.. J. Clin. Endocrinol. Metab. 40 (4): 720-3.
  • Nakamura S, Rodbell M (1991). Glucagon induces disaggregation of polymer-like structures of the alpha subunit of the stimulatory G protein in liver membranes.. Proc. Natl. Acad. Sci. U.S.A. 88 (16): 7150-4.
  • Horuk R, Wright DE (1983). Partial purification and characterization of the glucagon receptor.. FEBS Lett. 155 (2): 213-7.
  • MacNeil DJ, Occi JL, Hey PJ, et al. (1994). Cloning and expression of a human glucagon receptor.. Biochem. Biophys. Res. Commun. 198 (1): 328-34.
  • Fujisawa T, Ikegami H, Yamato E, et al. (1995). A mutation in the glucagon receptor gene (Gly40Ser): heterogeneity in the association with diabetes mellitus.. Diabetologia 38 (8): 983-5.
  • Hager J, Hansen L, Vaisse C, et al. (1995). A missense mutation in the glucagon receptor gene is associated with non-insulin-dependent diabetes mellitus.. Nat. Genet. 9 (3): 299-304.
  • Menzel S, Stoffel M, Espinosa R, et al. (1994). Localization of the glucagon receptor gene to human chromosome band 17q25.. Genomics 20 (2): 327-8.
  • Lok S, Kuijper JL, Jelinek LJ, et al. (1994). The human glucagon receptor encoding gene: structure, cDNA sequence and chromosomal localization.. Gene 140 (2): 203-9.
  • Unson CG, Macdonald D, Merrifield RB (1993). The role of histidine-1 in glucagon action.. Arch. Biochem. Biophys. 300 (2): 747-50.
  • Chambers SM, Morris BJ (1996). Glucagon receptor gene mutation in essential hypertension.. Nat. Genet. 12 (2): 122.
  • Yamato E, Ikegami H, Takekawa K, et al. (1997). Tissue-specific and glucose-dependent expression of receptor genes for glucagon and glucagon-like peptide-1 (GLP-1).. Horm. Metab. Res. 29 (2): 56-9.
  • Strazzullo P, Iacone R, Siani A, et al. (2001). Altered renal sodium handling and hypertension in men carrying the glucagon receptor gene (Gly40Ser) variant.. J. Mol. Med. 79 (10): 574-80.
  • Shiota D, Kasamatsu T, Dib SA, et al. (2002). Role of the Gly40Ser mutation in the glucagon receptor gene in Brazilian patients with type 2 diabetes mellitus.. Pancreas 24 (4): 386-90.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903.
  • Runge S, Gram C, Brauner-Osborne H, et al. (2003). Three distinct epitopes on the extracellular face of the glucagon receptor determine specificity for the glucagon amino terminus.. J. Biol. Chem. 278 (30): 28005-10.
  • Hassel S, Eichner A, Yakymovych M, et al. (2004). Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry.. Proteomics 4 (5): 1346-58.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 14 (10B): 2121-7.
  • Mortensen OH, Dichmann DS, Abrahamsen N, et al. (2007). Identification of a novel human glucagon receptor promoter: regulation by cAMP and PGC-1alpha.. Gene 393 (1-2): 127-36.

External linksEdit

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