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Gi alpha subunit

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guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
Symbol(s): GNAI1
Locus: 7 q21 -q22
EC number [1]
EntrezGene 2770
OMIM 139310
RefSeq NM_002069
UniProt P63096
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
Symbol(s): GNAI2 GNAI2B
Locus: 3 p21
EC number [2]
EntrezGene 2771
OMIM 139360
RefSeq NM_002070
UniProt P04899
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
Symbol(s): GNAI3
Locus: 1 p13
EC number [3]
EntrezGene 2773
OMIM 139370
RefSeq NM_006496
UniProt P08754

Gi alpha subunit (or Gi/G0 or Gi protein) is a heterotrimeric G protein subunit which inhibits the production of cAMP from ATP.

ReceptorsEdit

The following G-protein coupled receptors couple to the Gi subunit:

FunctionEdit

Further reading: function of cAMP-dependent protein kinase

Gi inhibits the production of cAMP from ATP, which, in turn, results in decreased activity of cAMP-dependent protein kinase. Thus, the ultimate effect of Gi is thus the opposite of cAMP-dependent protein kinase, which can be found at function of cAMP-dependent protein kinase.

TypesEdit

There are several types of Gi: Gia1, Gia2, Gia3 and Gia4

Gia1Edit

Gia1 or Gi1 is encoded by the gene GNAI1.

Gia2Edit

Gia2 or Gi2 is encoded by the gene GNAI2.

Gia3Edit

Gia3 or Gi3 is encoded by the gene GNAI3.

See alsoEdit

External linksEdit


Template:GTPases

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