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|guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1|
|Locus:||7 q21 -q22|
|guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2|
|guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3|
The following G-protein coupled receptors couple to the Gi subunit:
Further reading: function of cAMP-dependent protein kinase
Gi inhibits the production of cAMP from ATP, which, in turn, results in decreased activity of cAMP-dependent protein kinase. Thus, the ultimate effect of Gi is thus the opposite of cAMP-dependent protein kinase, which can be found at function of cAMP-dependent protein kinase.
There are several types of Gi: Gia1, Gia2, Gia3 and Gia4
Gia1 or Gi1 is encoded by the gene GNAI1.
Gia2 or Gi2 is encoded by the gene GNAI2.
Gia3 or Gi3 is encoded by the gene GNAI3.
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