Gi alpha subunit
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| guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | |
|---|---|
| Symbol(s): | GNAI1 |
| Locus: | 7 q21 -q22 |
| EC number | [1] |
| EntrezGene | 2770 |
| OMIM | 139310 |
| RefSeq | NM_002069 |
| UniProt | P63096 |
| guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | |
|---|---|
| Symbol(s): | GNAI2 GNAI2B |
| Locus: | 3 p21 |
| EC number | [2] |
| EntrezGene | 2771 |
| OMIM | 139360 |
| RefSeq | NM_002070 |
| UniProt | P04899 |
| guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | |
|---|---|
| Symbol(s): | GNAI3 |
| Locus: | 1 p13 |
| EC number | [3] |
| EntrezGene | 2773 |
| OMIM | 139370 |
| RefSeq | NM_006496 |
| UniProt | P08754 |
Gi alpha subunit (or Gi/G0 or Gi protein) is a heterotrimeric G protein subunit which inhibits the production of cAMP from ATP.
Contents |
Receptors
Edit
The following G-protein coupled receptors couple to the Gi subunit:
- 5-HT receptor type 1
- Adenosine receptor A1 and A3
- Prostaglandins
FunctionEdit
Further reading: function of cAMP-dependent protein kinase
Gi inhibits the production of cAMP from ATP, which, in turn, results in decreased activity of cAMP-dependent protein kinase. Thus, the ultimate effect of Gi is thus the opposite of cAMP-dependent protein kinase, which can be found at function of cAMP-dependent protein kinase.
TypesEdit
There are several types of Gi: Gia1, Gia2, Gia3 and Gia4
Gia1Edit
Gia1 or Gi1 is encoded by the gene GNAI1.
Gia2Edit
Gia2 or Gi2 is encoded by the gene GNAI2.
Gia3Edit
Gia3 or Gi3 is encoded by the gene GNAI3.
See alsoEdit
External linksEdit
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