Genetics of olfaction

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Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)

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There are a wide range of different odor receptors, with as many as 1000 in the mammalian genome. Olfactory receptors may make up as much as 3% of the genome. Only a portion of these potential genes form functional odor receptors. According to an analysis of the Human genome project, humans have 347 functional genes coding for olfactory receptors. The reason for the large number of different odor receptors is to provide a system for detecting as many different odors as possible. Even so, each odor receptor does not correspond to just one odor. Each individual odor receptor is broadly tuned to be activated by a number of similar structures. Like the immune system, this system allows molecules that have never been encountered before to be characterized. Also most odors activate more than one type of odor receptor. This aspect provides for the identification of an almost limitless number of different molecules.

Key texts

Papers

• Buck, L. and Axel, R. (1991) A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell, 65, 175–187.
• Malnic, B., Godfrey, P.A., & Buck, L.B. (2004). The human olfactory receptor gene family. Proceedings of the National Academy of Sciences, USA, 24;101(8):2584-2589.

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