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There are three SNPs (single nucleotide polymorphisms) along the gene that may render its proteins unresponsive. There is conflicting evidence as to whether the inheritance of this trait is dominant or incomplete dominant. Any person with a single functional copy of this gene can make the protein and is sensitive to PTC. Some studies have shown that homozygous tasters experience a more intense bitterness than people that are heterozygous; other studies have indicated that another gene may determine taste sensitivity.
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- ↑ Kim UK, Jorgenson E, Coon H, Leppert M, Risch N, Drayna D (2003). Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide. Science 299 (5610): 1221–1225.
- ↑ (2012). Genetic study of phenylthiocarbamide (PTC) taste perception among six human populations of Jammu and Kashmir (India). Egypt J Med Hum Genet 13 (2).