Fandom

Psychology Wiki

Genetic counseling: HIgA Nephropathy

34,203pages on
this wiki
Add New Page
Talk0 Share

Assessment | Biopsychology | Comparative | Cognitive | Developmental | Language | Individual differences | Personality | Philosophy | Social |
Methods | Statistics | Clinical | Educational | Industrial | Professional items | World psychology |

Clinical: Approaches · Group therapy · Techniques · Types of problem · Areas of specialism · Taxonomies · Therapeutic issues · Modes of delivery · Model translation project · Personal experiences ·


IgA Nephropathy

What is IgA Nephropathy?Edit

  • the most common non-diabetic kidney disease
  • IgA, a normal component of the blood, collects in the kidney as damaging deposits
  • due to either increased production or reduced clearance of the immune protein IgA and associated antigen complexes
  • deposits collect in small blood vessels in the glomeruli (the filtering structure of the kidney)
  • 20%- 30% of patients will suffer eventual kidney failure within 10-20 years
  • more likely if they have high levels of creatinine in blood at time of diagnosis
  • will require life saving dialysis and/or a kidney transplant
  • a large proportion of patients who present with symptoms have a mild form of the disease
  • most people probably never know they have the disease or discover it at a late stage

Warning Signs of Kidney DiseaseEdit

  • tea colored urine (hematuria - blood in the urine)
  • very foamy urine (proteinuria - protein in the urine)
  • puffiness around the eyes, hands, or feet (edema - fluid retention)
  • high blood pressure
  • pain in the small of the back just below the ribs not aggravated by motion.
  • frequent urge to urinate especially at night, and/or reduced amount of urine produced

TreatmentEdit

  • no medical treatments except in the latest stages of the disease
  • transplant success rate is good (symptoms mild, though deposits will appear in the transplanted kidney after one year)
  • some therapies can delay the deterioration of kidney function for many years
  • ACE inhibitors, fish oil, steroid treatment, tonsillectomy
  • control of associated hypertension is important

DiagnosisEdit

  • the presence of blood and/or protein in the urine
  • some nephrologists may microscopically examination urine and red blood cell casts
  • to confirm a diagnosis, it is necessary to perform a renal biopsy and examine kidney tissue microscopically for the presence of the characteristic IgA deposits in the glomeruli
  • no genetic testing available

CausesEdit

  • unknown (recurrence risk also unknown)
  • genetic influences may play a role in the development of the disease
  • seems to cluster in certain families and in certain areas of the world
  • associated with major histocompatibility HLA and certain other genetic markers
  • HLA-DR4 is detectable in about 50% of patients

NotesEdit

The information in this outline was last updated in 2001.


This material has been imported fom the wikibook "Genetic counseling"[ http://en.wikibooks.org/wiki/Genetic_counseling] under the GNU Free Documentation License.

Heckert GNU white Permission is granted to copy, distribute and/or modify this document under the terms of the GNU Free Documentation License, Version 1.2 or any later version published by the Free Software Foundation; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts. A copy of the license is included in the section entitled "GNU Free Documentation License."

Ad blocker interference detected!


Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers

Wikia is not accessible if you’ve made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected.

Also on Fandom

Random Wiki