Galanin receptor
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| galanin receptor 1 | |
|---|---|
| Symbol(s): | GALR1 GALNR1, GALNR |
| Locus: | 18 q23 |
| EC number | [1] |
| EntrezGene | 2587 |
| OMIM | 600377 |
| RefSeq | NM_001480 |
| UniProt | P47211 |
| galanin receptor 2 | |
|---|---|
| Symbol(s): | GALR2 |
| Locus: | 17 q25.3 |
| EC number | [2] |
| EntrezGene | 8811 |
| OMIM | 603691 |
| RefSeq | NM_003857 |
| UniProt | O43603 |
| galanin receptor 3 | |
|---|---|
| Symbol(s): | GALR3 |
| Locus: | 22 q12.2 -13.1 |
| EC number | [3] |
| EntrezGene | 8484 |
| OMIM | 603692 |
| RefSeq | NM_003614 |
| UniProt | O60755 |
The galanin receptor is a G protein-coupled receptor, or metabotropic receptor which binds galanin.[1]
So far three subtypes are known to exist: GAL-R1, GAL-R2, and GAL-R3.[2] The specific function of each subtype remains to be fully elucidated, although great progress is currently being made in this respect with the generation of receptor subtype-specific knockout mice.
Galanin receptors can be found throughout the peripheral and central nervous systems and the endocrine system.
References
- ↑ Lang R, Gundlach AL, Kofler B (2007). The galanin peptide family: receptor pharmacology, pleiotropic biological actions, and implications in health and disease. Pharmacol. Ther. 115 (2): 177–207.
- ↑ Branchek TA, Smith KE, Gerald C, Walker MW (2000). Galanin receptor subtypes. Trends Pharmacol. Sci. 21 (3): 109–17.
External links
- Galanin Receptors. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
- MeSH Galanin+Receptors
Neuropeptide receptors | |
|---|---|
| Hypothalamic hormone receptors |
CRH - FSH - LHRH - TRH - Somatostatin |
| Pituitary hormone receptors |
Vasopressin (1A, 1B, 2) - Oxytocin - LHCG - Type I cytokine receptor (GH, Prolactin) - TSH |
| Other hormone receptors |
Atrial natriuretic factor - Calcitonin - Cholecystokinin - VIP |
| Opioid receptors | |
| Other neuropeptide receptors |
Angiotensin - Bradykinin/Tachykinin (TACR1) - Calcitonin gene-related peptide - Galanin - GPCR neuropeptide (B/W, FF, S, Y) - Neurotensin |
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