Galactose
From Psychology Wiki
Community portal · Tasks to do · News · Help
Clinical · Educational · Ind&Org · Other fields · Professional · Transpersonal · World
Assessment | Biopsychology | Comparative | Cognitive | Developmental | Language | Personality | Philosophy | Research Methods | Social | Statistics
Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology
| style="background: #F8EABA; text-align: center;" colspan="2" | Galactose |
|---|---|
| Identifiers | |
| Properties | |
| Hazards | |
| style="background: #F8EABA; text-align: center;" colspan="2" | Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
Galactose (Gal) (also called Brain Sugar) is a type of sugar which is less sweet than glucose and not very water-soluble. It is considered a nutritive sweetener because it has food energy.
Galactan is a polymer of the sugar galactose. It is found in hemicellulose and can be converted to galactose by hydrolysis.
Contents |
[edit] Sources
It is found in dairy products, in sugar beets and other gums and mucilages.
It is also synthesized by the body, where it forms part of glycolipids and glycoproteins in several tissues.
[edit] Relationship to lactose
Galactose is a monosaccharide constituent, together with glucose, of the disaccharide lactose. The hydrolysis of lactose to glucose and galactose is catalyzed by the enzyme lactase, a β-galactosidase. In the human body, glucose is changed into galactose in order to enable the mammary glands to secrete lactose.
Galactose and glucose are produced by hydrolysis of lactose by ß-galactosidase. This enzyme is produced by the lac operon in Escherichia coli (E. coli).
[edit] Clinical significance
Two studies have suggested a possible link between galactose in milk and ovarian cancer.[1][2] Other studies failed to show such a link.[citation needed]
There are some ongoing studies which suggest that Galactose may have a role in treatment of focal segmental glomerulosclerosis (a kidney disease resulting in kidney failure and proteinuria).[citation needed] This effect is likely to be a result of binding of Galactose to FSGS factor.[citation needed]
[edit] Structure and isomerism
The first and last -OH groups point the same way and the second and third -OH groups point the other way. D-Galactose has the same configuration at its penultimate carbon as D-glyceraldehyde. Galactose is an optical isomer of glucose.
[edit] Liver galactose metabolism
In the liver, galactose is converted to glucose 6-phosphate in the following reactions:
galacto- uridyl phosphogluco-
kinase transferase mutase
gal --------> gal 1 P ------------------> glc 1 P -----------> glc 6 P
^ \
/ v
UDP-glc UDP-gal
^ /
\___________/
epimerase
[edit] Metabolic disorders
There are 3 important disorders involving galactose:
| Name | Enzyme | Description |
| Galactosemia | Galactokinase | Causes cataracts and mental retardation. If a galactose-free diet starts sufficiently early, the cataracts will regress without complications however neurological damage is permanent. |
| UDPgalactose-4-epimerase deficiency | UDPgalactose-4-epimerase | Is extremely rare (only 2 reported cases). It causes nerve deafness. |
| Galactose-1-phosphate uridyl transferase deficiency | Galactose-1-phosphate uridyl transferase | Is the most problematic, as galactose-free diets do not have considerable long-term effects. |
[edit] References
- ↑ Cramer D (1989). Lactase persistence and milk consumption as determinants of ovarian cancer risk. Am J Epidemiol 130 (5): 904-10.
- ↑ Cramer D, Harlow B, Willett W, Welch W, Bell D, Scully R, Ng W, Knapp R (1989). Galactose consumption and metabolism in relation to the risk of ovarian cancer. Lancet 2 (8654): 66-71.
[edit] External links
| General: | Aldose | Ketose | Pyranose | Furanose | |
|---|---|---|
| Geometry: | Triose | Tetrose | Pentose | Hexose | Heptose | Cyclohexane conformation | Anomer | Mutarotation | |
| Small/Large: | Glyceraldehyde | Dihydroxyacetone | Erythrose | Threose | Erythrulose | Sedoheptulose | |
| Trioses: | ketotriose | Aldotriose | |
| Tetroses: | Erythrulose | Erythrose | Threose | |
| Pentoses: | Arabinose | Deoxyribose | Lyxose | Ribose | Ribulose | Xylose | Xylulose | |
| Hexoses: | Glucose | Galactose | Mannose | Gulose | Idose | Talose | Allose | Altrose | Fructose | Sorbose | Tagatose | Psicose | Fucose | Rhamnose | |
| Disaccharides: | Sucrose | Lactose | Trehalose | Maltose | |
| Polymers: | Glycogen | Starch (Amylose | Amylopectin) | Cellulose | Chitin | Stachyose | Inulin | Dextrin | |
| Glycosaminoglycans: | Heparin | Chondroitin sulfate | Hyaluronan | Heparan sulfate | Dermatan sulfate | Keratan sulfate | |
| Aminoglycosides: | Kanamycin | Streptomycin | Tobramycin | Neomycin | Paromomycin | Apramycin | Gentamicin | Netilmicin | Amikacin | |
| This page uses content from the English-language version of Wikipedia. The original article was at Galactose. The list of authors can be seen in the page history. As with Psychology Wiki, the text of Wikipedia is available under the GNU Free Documentation License. |
