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GABA transporter 1

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GABA transporter 1 (GAT-1) also known as sodium- and chloride-dependent GABA transporter 1 is a protein that in humans is encoded by the SLC6A1 gene.[1][2]

Function Edit

GAT-1 a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft.[3]

Interactions Edit

SLC6A1 has been shown to interact with STX1A.[4][5][6]

See also Edit

References Edit

  1. Huang F, Shi LJ, Heng HH, Fei J, Guo LH (February 1996). Assignment of the human GABA transporter gene (GABATHG) locus to chromosome 3p24-p25. Genomics 29 (1): 302–4.
  2. Entrez Gene: SLC6A1 solute carrier family 6 (neurotransmitter transporter, GABA), member 1.
  3. Hirunsatit R, George ED, Lipska BK, Elwafi HM, Sander L, Yrigollen CM, Gelernter J, Grigorenko EL, Lappalainen J, Mane S, Nairn AC, Kleinman JE, Simen AA (January 2009). Twenty-one-base-pair insertion polymorphism creates an enhancer element and potentiates SLC6A1 GABA transporter promoter activity. Pharmacogenet. Genomics 19 (1): 53–65.
  4. Beckman, M L, Bernstein E M, Quick M W (August 1998). Protein kinase C regulates the interaction between a GABA transporter and syntaxin 1A. J. Neurosci. 18 (16): 6103–12.
  5. Quick, Michael W (April 2002). Substrates regulate gamma-aminobutyric acid transporters in a syntaxin 1A-dependent manner. Proc. Natl. Acad. Sci. U.S.A. 99 (8): 5686–91.
  6. Deken, S L, Beckman M L, Boos L, Quick M W (October 2000). Transport rates of GABA transporters: regulation by the N-terminal domain and syntaxin 1A. Nat. Neurosci. 3 (10): 998–1003.

Further reading Edit

  • Nelson H, Mandiyan S, Nelson N (1990). Cloning of the human brain GABA transporter.. FEBS Lett. 269 (1): 181–4.
  • Bennett ER, Kanner BI (1997). The membrane topology of GAT-1, a (Na+ + Cl-)-coupled gamma-aminobutyric acid transporter from rat brain.. J. Biol. Chem. 272 (2): 1203–10.
  • Bismuth Y, Kavanaugh MP, Kanner BI (1997). Tyrosine 140 of the gamma-aminobutyric acid transporter GAT-1 plays a critical role in neurotransmitter recognition.. J. Biol. Chem. 272 (26): 16096–102.
  • DeFelipe J, González-Albo MC (1998). Chandelier cell axons are immunoreactive for GAT-1 in the human neocortex.. Neuroreport 9 (3): 467–70.
  • Conti F, Melone M, De Biasi S, et al. (1998). Neuronal and glial localization of GAT-1, a high-affinity gamma-aminobutyric acid plasma membrane transporter, in human cerebral cortex: with a note on its distribution in monkey cortex.. J. Comp. Neurol. 396 (1): 51–63.
  • Beckman ML, Bernstein EM, Quick MW (1998). Protein kinase C regulates the interaction between a GABA transporter and syntaxin 1A.. J. Neurosci. 18 (16): 6103–12.
  • Augood SJ, Waldvogel HJ, Münkle MC, et al. (1999). Localization of calcium-binding proteins and GABA transporter (GAT-1) messenger RNA in the human subthalamic nucleus.. Neuroscience 88 (2): 521–34.
  • Ong WY, Yeo TT, Balcar VJ, Garey LJ (2000). A light and electron microscopic study of GAT-1-positive cells in the cerebral cortex of man and monkey.. J. Neurocytol. 27 (10): 719–30.
  • Deken SL, Beckman ML, Boos L, Quick MW (2000). Transport rates of GABA transporters: regulation by the N-terminal domain and syntaxin 1A.. Nat. Neurosci. 3 (10): 998–1003.
  • Whitworth TL, Quick MW (2001). Substrate-induced regulation of gamma-aminobutyric acid transporter trafficking requires tyrosine phosphorylation.. J. Biol. Chem. 276 (46): 42932–7.
  • Hachiya Y, Takashima S (2002). Development of GABAergic neurons and their transporter in human temporal cortex.. Pediatr. Neurol. 25 (5): 390–6.
  • Quick MW (2002). Substrates regulate gamma-aminobutyric acid transporters in a syntaxin 1A-dependent manner.. Proc. Natl. Acad. Sci. U.S.A. 99 (8): 5686–91.
  • Kanner BI (2003). Transmembrane domain I of the gamma-aminobutyric acid transporter GAT-1 plays a crucial role in the transition between cation leak and transport modes.. J. Biol. Chem. 278 (6): 3705–12.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.
  • Zomot E, Kanner BI (2003). The interaction of the gamma-aminobutyric acid transporter GAT-1 with the neurotransmitter is selectively impaired by sulfhydryl modification of a conformationally sensitive cysteine residue engineered into extracellular loop IV.. J. Biol. Chem. 278 (44): 42950–8.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). Complete sequencing and characterization of 21,243 full-length human cDNAs.. Nat. Genet. 36 (1): 40–5.
  • Zhou Y, Bennett ER, Kanner BI (2004). The aqueous accessibility in the external half of transmembrane domain I of the GABA transporter GAT-1 Is modulated by its ligands.. J. Biol. Chem. 279 (14): 13800–8.
  • Hu JH, Ma YH, Jiang J, et al. (2004). Cognitive impairment in mice over-expressing gamma-aminobutyric acid transporter 1 (GAT1).. Neuroreport 15 (1): 9–12.
  • Korkhov VM, Farhan H, Freissmuth M, Sitte HH (2005). Oligomerization of the {gamma}-aminobutyric acid transporter-1 is driven by an interplay of polar and hydrophobic interactions in transmembrane helix II.. J. Biol. Chem. 279 (53): 55728–36.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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