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|gamma-aminobutyric acid (GABA) B receptor, 1|
|gamma-aminobutyric acid (GABA) B receptor, 2|
|Locus:||9 q22.1 -22.3|
GABAB receptors (GABABR) are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA) that are linked via G-proteins to potassium channels. These receptors are found in the central and peripheral autonomic nervous system.
They can stimulate the opening of K+ channels which brings the neuron closer to the equilibrium potential of K+, hyperpolarising the neuron. This prevents sodium channels from opening, action potentials from firing, and VDCCs from opening, and so stops neurotransmitter release. Thus GABAB receptors are considered inhibitory receptors.
GABAB receptors are involved in behavioral actions of ethanol,  gamma-Hydroxybutyric acid (GHB), and possibly in pain. Recent research suggests that these receptors may play an important developmental role. 
GABABRs are similar in structure to and in the same receptor family with metabotropic glutamate receptors. There are two subtypes of the receptor, GABAB1 and GABAB2, and these appear to assemble as heterodimers in neuronal membranes by linking up by their intracellular C termini.
Agonists and antagonistsEdit
- ↑ Chen K, Li H, Ye N, Zhang J, Wang J (2005). Role of GABAB receptors in GABA and baclofen-induced inhibition of adult rat cerebellar interpositus nucleus neurons in vitro. Brain Res Bull 67 (4): 310-8.
- ↑ 2.0 2.1 2.2 2.3 2.4 Martin I.L., and Dunn S.M.J. 2002. GABA receptors Tocris Cookson Ltd.
- ↑ Dzitoyeva S, Dimitrijevic N, Manev H (2003). Gamma-aminobutyric acid B receptor 1 mediates behavior-impairing actions of alcohol in Drosophila: adult RNA interference and pharmacological evidence. Proc Natl Acad Sci U S A 100 (9): 5485-90.
- ↑ Dimitrijevic N, Dzitoyeva S, Satta R, Imbesi M, Yildiz S, Manev H (2005). Drosophila GABA(B) receptors are involved in behavioral effects of gamma-hydroxybutyric acid (GHB). Eur J Pharmacol 519 (3): 246-52.
- ↑ Manev H, Dimitrijevic N (2004). Drosophila model for in vivo pharmacological analgesia research. Eur J Pharmacol 491 (2-3): 207-8.
- ↑ Dzitoyeva S, Gutnov A, Imbesi M, Dimitrijevic N, Manev H (2005). Developmental role of GABAB(1) receptors in Drosophila. Brain Res Dev Brain Res 158 (1-2): 111-4.
- ↑ 7.0 7.1 MRC (Medical Research Counsil). 2003. Glutamate receptors: Structures and functions. University of Brisotol Centre for Synaptic Plasticity.
- ↑ Purves D., Augustine G.J., Fitzpatrick D., Katz L.C., LaMantia A.S., McNamara J.O., and Williams S.M. 2001. Neuroscience, Second Edition. Sinauer Associates, Inc.
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