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Frontostriatal circuits connect frontal lobe regions with the basal ganglia and mediate motor, cognitive, and behavioural programs within the brain (Alexander et al., 1986, 1990) and receive inputs from dopaminergic, serotonergic, noradrenergic, and cholinergic cell groups that modulate information processing (Tekin and Cummings, 2002). These are affected by Parkinson's disease and contribute to the non-motor symptoms associated with it.

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