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Adiposogenital dystrophy

Redirected from Frölich's syndrome

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Adiposogenital dystrophy
ICD-10 E236
ICD-9 253.8
OMIM [1]
DiseasesDB 29318
MedlinePlus [2]
eMedicine /
MeSH {{{MeshNumber}}}

Adiposogenital dystrophy is an Endocrine disorder which may be caused by secondary hypogonadism originating from decreased levels in GnRH. Low levels of GnRH has been associated with defects of the feeding centers of the hypothalamus, leading to an increase consumption of food and thus caloric intake.


It is characterized by:

It is usually associated with tumours of the hypothalamus, causing increased appetite and depressed secretion of gonadotropin. It seems to affect males mostly.

Many overweight children may appear to have the disorder because of the concurrence of obesity and retarded sexual development; these children have no endocrine disturbances, however, and they mature normally after delayed puberty.


It has several other names:[1]

See alsoEdit


  1. National Organisation for Rare Disorders - Froelich's syndrome
  2. Who Named It synd/1792 - Babinski-Fröchlich syndrome
  3. J. F. Babinski. Tumeur du corps pituitaire sans acromégalie et avec arrêt de développement des organes génitaux. Revue neurologique, Paris, 1900, 8: 531-535.
  4. A. Fröhlich. Ein Fall von Tumor der Hypophysis cerebri ohne Akromegalie. Wiener klinische Rundschau, 1901, 15: 833-836; 906-908.
  5. Zárate A, Saucedo R (2007). [The adiposogenital distrophy or Frohlich syndrome and the beginning of the concept of neuroendocrinology]. Gac Med Mex 143 (4): 349–50.

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