2C (psychedelics)

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2C is a general name for the family of psychedelic and entheogenic phenethylamines containing methoxy groups on the 2 and 5 positions of the benzene ring. There is also usually a substitute on the 4 position to avoid excessive metabolism and thus be active on the CNS. Most of the currently known 2C's were first synthesized by Alexander Shulgin in the 70's and 80's, and recorded in his book, PiHKAL (Phenethylamines I Have Known And Loved). Dr. Shulgin also invented the term 2C, being an acronym for the 2 carbon atoms between the benzene ring and the amino group (the amphetamine counterparts are sometimes known as 3C's).

General structure of a 2C

Skeletal formula of 2C-T-7

Skeletal formula of 2C-T-21

Nomenclature	R3	R4	2D Structure	3D Structure
2C-B	H	Br
2C-C	H	Cl
2C-D	H	CH3
2C-E	H	CH2CH3
2C-F	H	F
2C-G	CH3	CH3
2C-G-3	(CH2)3
2C-G-4	(CH2)4
2C-G-N	(CH)4
2C-H	H	H
2C-I	H	I
2C-N	H	NO2
2C-O	H	OCH3
2C-O-4	H	OCH(CH3)2
2C-P	H	CH2CH2CH3
2C-SE	H	SeCH3
2C-T	H	SCH3
2C-T-2	H	SCH2CH3
2C-T-4	H	SCH(CH3)2
2C-T-7	H	S(CH2)2CH3
2C-T-8	H	SCH2CH(CH2)2
2C-T-9	H	SC(CH3)3
2C-T-13	H	S(CH2)2OCH3
2C-T-15	H	SCH(CH2)2
2C-T-17	H	SCH(CH3)CH2CH3
2C-T-21	H	S(CH2)2F
2C-TFM	H	CF3

See Also

Substituted Amphetamines

External Links

• Book II of PiHKAL.