Extraglomerular mesangial cells
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Extraglomerular mesangial cells (or lacis cells) are light-staining cells in the kidney found outside the glomerulus, near the vascular pole and macula densa.
Lacis cells form the juxtaglomerular apparatus in combination with two other types of cells: the macula densa of the distal convoluted tubule and Juxtaglomerular cells of the afferent arteriole. This apparatus controls blood pressure through the Renin-Angiotensin-Aldosterone system. The specific function of Lacis cells is not well understood, although it has been associated with the secretion of erythropoietin. [1]
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- ↑ Junqueira, Luiz C.; Jose Carneiro (2003). Basic Histology, McGraw-Hill. ISBN 0838505902.
| Urinary system - Kidney - edit |
|---|
| Renal capsule | Renal cortex | Renal medulla (Renal sinus, Renal pyramids) | Renal calyx | Renal pelvis |
| Nephron - Renal corpuscle (Glomerulus, Bowman's capsule) → Proximal tubule → Loop of Henle → Distal convoluted tubule → Collecting ducts
Juxtaglomerular apparatus (Macula densa, Juxtaglomerular cells) Renal circulation - Renal artery → Interlobar arteries → Arcuate arteries → Cortical radial arteries → Afferent arterioles → Glomerulus → Efferent arterioles → Vasa recta → Arcuate vein → Renal vein |
| Renal physiology |
| Filtration - Ultrafiltration | Countercurrent exchange
Hormones effecting filtration - Antidiuretic hormone (ADH) | Aldosterone | Atrial natriuretic peptide Endocrine - Renin | Erythropoietin (EPO) | Calcitriol (Active vitamin D) | Prostaglandins |
| Assessing Renal function / Measures of Dialysis |
| Glomerular filtration rate | Creatinine clearance | Renal clearance ratio | Urea reduction ratio | Kt/V | Standardized Kt/V | Hemodialysis product |
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