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Estrone

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Estrone chemical structure
Estrone

3-hydroxy-13-methyl- 6,7,8,9,11,12,13,14,15,16- decahydrocyclopenta[a]phenanthren- 17- one
IUPAC name
CAS number
53-16-7
ATC code

G03CA07 .

PubChem
5870
DrugBank
APRD00588
Chemical formula {{{chemical_formula}}}
Molecular weight 270.366 g/mol
Bioavailability
Metabolism
Elimination half-life 19 hours
Excretion
Pregnancy category
Legal status
Routes of administration

Estrone (also oestrone) is an estrogenic hormone secreted by the ovary as well as adipose.

Estrone is one of the three estrogens, which also include estriol and estradiol. Estrone is the least abundant of the three hormones, estradiol is present almost always in the reproductive female body, and estriol is abundant primarily during pregnancy.

Estrone is relevant to health and disease states because of its conversion to estrone sulfate, a long-lived derivative. Estrone sulfate acts as a reservoir that can be converted as needed to the more active estradiol.

Estrone is the only one of the three estrogens which is present in any quantity in post-menopausal women.

SynthesisEdit

Estrone is synthesized via aromatase from androstenedione, a derivative of progesterone. The conversion consists of the de-methylation of C-19 and the aromaticity of the 'A' ring. This reaction is similar to the conversion of testosterone to estradiol.

Additional imagesEdit


Template:Cholesterol and steroid intermediates


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