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Epoxyeicosatrienoic acid

Chemical structure of 14,15-epoxyeicosatrienoic acid.

The Epoxyeicosatrienoic acids or EETs are signaling molecules formed by the action of Cytochrome P450 epoxygenase on 20-carbon essential fatty acids, such as arachidonic acid. They act as short-range hormones, (i.e. they are autocrine and paracrine mediators) of the cardiovascular system and kidney. They produce vasorelaxation as well as anti-inflammatory and pro-fibrinolytic effects.[1] Technically they are eicosanoids, though the common use of that term does not yet include them.

Biological effectsEdit

EETs are cardioprotective after ischemic heart attack and reperfusion.[2] They act in the corpus cavernosumto maintain penile erection.[3]


  1. ^  Nithipatikom K, Moore JM, Isbell MA, Falck JR, Gross GJ.. Epoxyeicosatrienoic acids (EETs) in cardioprotection: Ischemic versus reperfusion injury.. Am J Physiol Heart Circ Physiol. date=2006 Feb 10. URL accessed on 2006-03-11.
  2. ^  Jin L, Foss CE, Zhao X, Mills TM, Wang MH, McCluskey LP, Yaddanapud GS, Falck JR, Imig JD, Webb RC.. Cytochrome P450 epoxygenases provide a novel mechanism for penile erection.. FASEB J. 2006 Mar;20(3):539-41.. URL accessed on 2006-03-11.PubMed cite.
  3. ^ Spector AA,Fang X, Snyder GD, Weintraub NL (Jan 2004). Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function. Prog Lipid Res 43 (1): 55-90. PMID 14636671.


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