Psychology Wiki

Epoxyeicosatrienoic acid

34,203pages on
this wiki
Add New Page
Talk0 Share

Assessment | Biopsychology | Comparative | Cognitive | Developmental | Language | Individual differences | Personality | Philosophy | Social |
Methods | Statistics | Clinical | Educational | Industrial | Professional items | World psychology |

Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)

Epoxyeicosatrienoic acid

Chemical structure of 14,15-epoxyeicosatrienoic acid.

The Epoxyeicosatrienoic acids or EETs are signaling molecules formed by the action of Cytochrome P450 epoxygenase on 20-carbon essential fatty acids, such as arachidonic acid. They act as short-range hormones, (i.e. they are autocrine and paracrine mediators) of the cardiovascular system and kidney. They produce vasorelaxation as well as anti-inflammatory and pro-fibrinolytic effects.[1] Technically they are eicosanoids, though the common use of that term does not yet include them.

Biological effectsEdit

EETs are cardioprotective after ischemic heart attack and reperfusion.[2] They act in the corpus cavernosumto maintain penile erection.[3]


  1. ^  Nithipatikom K, Moore JM, Isbell MA, Falck JR, Gross GJ.. Epoxyeicosatrienoic acids (EETs) in cardioprotection: Ischemic versus reperfusion injury.. Am J Physiol Heart Circ Physiol. date=2006 Feb 10. URL accessed on 2006-03-11.
  2. ^  Jin L, Foss CE, Zhao X, Mills TM, Wang MH, McCluskey LP, Yaddanapud GS, Falck JR, Imig JD, Webb RC.. Cytochrome P450 epoxygenases provide a novel mechanism for penile erection.. FASEB J. 2006 Mar;20(3):539-41.. URL accessed on 2006-03-11.PubMed cite.
  3. ^ Spector AA,Fang X, Snyder GD, Weintraub NL (Jan 2004). Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function. Prog Lipid Res 43 (1): 55-90. PMID 14636671.


This page uses Creative Commons Licensed content from Wikipedia (view authors).

Ad blocker interference detected!

Wikia is a free-to-use site that makes money from advertising. We have a modified experience for viewers using ad blockers

Wikia is not accessible if you’ve made further modifications. Remove the custom ad blocker rule(s) and the page will load as expected.

Also on Fandom

Random Wiki