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They produce and contain about 90% of the body's store of serotonin (5-HT).
In the gastrointestinal tract, 5-HT is important in response to chemical, mechanical or pathological stimuli in the lumen. It activates both secretory and peristaltic reflexes, and activates vagal afferents (via 5-HT3 receptors) that signal to the brain (important in the generation of nausea).
Another population of chromaffin cells is found only in the stomach wall, called enterochromaffin-like cells (ECL). They look "like" EC cells but do not contain 5-HT.
- ↑ MeSH Enterochromaffin+Cells
- ↑ http://www.medterms.com/script/main/art.asp?articlekey=3258
- ↑ GPnotebook 1516961798
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