Drug sensitivity

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Drug sensitivity or Drug intolerance is a lower threshold to the normal pharmacologic action of a drug. It is not to be confused with drug allergy. Drug intolerance is uncommon and idiopathic, thus extremely difficult to predict except in persons with a prior history or a family history of intolerance to that specific drug. Some drug intolerances are known to result from genetic variants of drug metabolism.

Contents 1 Examples 2 Analgesic intolerance 3 See also 4 References

[edit] Examples

• Tinnitus after a normal dose of aspirin
• Liver failure (possibly also kidney failure) after a normal dose of acetaminophen
• Fatal poisoning in a breastfed newborn baby due to normal use of codeine by the mother^[1]

[edit] Analgesic intolerance

Intolerance to analgesics, particularly NSAIDs, is relatively common. Its cause is believed to be variation in the metabolism of arachidonic acid. Symptoms include chronic rhinosinusitis with nasal polyps, asthma, gastrointestinal ulcers, angioedema, and urticaria.^[2]

[edit] See also

• Contraindication
• Drug tolerance
• Food intolerance

[edit] References

This page uses content from the English-language version of Wikipedia. The original article was at Drug intolerance. The list of authors can be seen in the page history. As with Psychology Wiki, the text of Wikipedia is available under the GNU Free Documentation License.