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Drug overdoses

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Drugs
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Drug type
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Drug overdose
ICD-10 T36-T50
ICD-9 960-979
OMIM [1]
DiseasesDB [2]
MedlinePlus [3]
eMedicine /
MeSH {{{MeshNumber}}}


The term drug overdose (or simply overdose or OD) describes the ingestion or application of a drug or other substance in quantities greater than are recommended[1] or generally practiced.[2] An overdose may result in a toxic state or death.[2]

ClassificationEdit

The word "overdose" implies that there is a common safe dosage and usage for the drug; therefore, the term is commonly only applied to drugs, not poisons, though even certain poisons are harmless at a low enough dosage.

Drug overdoses are sometimes caused intentionally to commit suicide or as self-harm, but many drug overdoses are accidental, the result of intentional or unintentional misuse of medication. Unintentional misuse leading to overdose can include using prescribed or unprescribed drugs in excessive quantities in an attempt to produce euphoria.

Usage of illicit drugs of unexpected purity, in large quantities, or after a period of drug abstinence can also induce overdose. Cocaine users who inject intravenously can easily overdose accidentally, as the margin between a pleasurable drug sensation and an overdose is small.[3]

Unintentional misuse can include errors in dosage caused by failure to read or understand product labels. Accidental overdoses may also be the result of over-prescription, failure to recognize a drug's active ingredient, or unwitting ingestion by children[4] A common unintentional overdose in young children involves multi-vitamins containing iron. Iron is a component of the hemoglobin molecule in blood, used to transport oxygen to living cells. When taken in small amounts, iron allows the body to replenish hemoglobin, but in large amounts it causes severe pH imbalances in the body. If this overdose is not treated with chelation therapy, it can lead to death or permanent coma.

The term 'overdose' is often misused as a descriptor for adverse drug reactions or negative drug interactions due to mixing multiple drugs simultaneously.

Signs and symptomsEdit

Toxidrome[5]
Symptoms BP HR RR Temp Pupils bowel soundsdiaphoresis
anticholinergic ~ up ~ up up down down
cholinergic ~ ~ unchanged unchanged down up up
opioid down down down down down down down
sympathomimetic up up up up up up up
sedative-hypnotic down down down down ~ down down

Signs and symptoms of an overdose varies depending on the drug or toxin exposure. The symptoms can often be divided into differing toxidromes. This can help one determine what class of drug or toxin is causing the difficulties.

Symptoms of opioid overdoses include slow breathing, heart rate and pulse.[6] Opioid overdoses can also cause pinpoint pupils, and blue lips and nails due to low levels of oxygen in the blood. A person experiencing an opioid overdose might also have muscle spasms, seizures and decreased consciousness. A person experiencing an opiate overdose usually will not wake up even if their name is called or if they are shaken vigorously.

CausesEdit

The drugs or toxins which are most frequently involved in overdose and death (grouped by ICD-10):

DiagnosisEdit

Determination of the substance which has been taken may often be determined by asking the person. However, if they will not, or cannot, due to an altered level of consciousness, provide this information, a search of the home or questioning of friends and family may be helpful.

Examination for toxidromes, drug testing, or laboratory test may be helpful. Other laboratory test such as glucose, urea and electrolytes, paracetamol levels and salicylate levels are typically done. Negative drug-drug interactions have sometimes been misdiagnosed as an acute drug overdose, occasionally leading to the assumption of suicide.[7]

PreventionEdit

The distribution of naloxone to injection drug users and other opioid drug users decreases the risk of death from overdose.[8] CDC estimates that US programs for drug users and their caregivers prescribing take-home doses of naloxone and training on its utilization are estimated to have reversed 10,000 opioid overdose deaths.[9][10] Healthcare institution-based naloxone prescription programs have also helped reduce rates of opioid overdose in the US state of North Carolina, and have been replicated in the US military.[11][12] Nevertheless, scale-up of healthcare-based opioid overdose interventions is limited by providers’ insufficient knowledge and negative attitudes towards prescribing take-home naloxone to prevent opioid overdose.[13] Programs training police and fire personnel in opioid overdose response using naloxone have also shown promise in the US.[14][15]

ManagementEdit

Stabilization of the ABCs are the initial treatment of an overdose. Ventilation is considered when there is a low respiratory rate or when blood gases show the person to be hypoxic. Monitoring of the patient should continue before and throughout the treatment process, with particular attention to temperature, pulse, respiratory rate, blood pressure, urine output, electrocardiography (ECG) and O2 saturation.[16] Poison control centers and Medical toxicologists are available in many areas to provide guidance in overdoses to both physicians and the general public.

AntidotesEdit

Specific antidotes are available for certain overdoses--for example, Naloxone is the antidote for opiates such as heroin or morphine. Charcoal is frequently recommended if available within one hour of the ingestion and the ingestion is significant.[17] Gastric lavage, syrup of ipecac, and whole bowel irrigation are rarely used.[17]

EpidemiologyEdit

The National Center for Health Statistics report that 19,250 people died of accidental poisoning in the U.S. in the year 2004 (8 deaths per 100,000 population).[18]

In 2008 testimony before a Senate subcommittee, Medical Epidemiologist Dr. Leonard J. Paulozzi[19] of the Centers for Disease Control and Prevention stated that in 2005 (the most recent year for which data was available) more than 22,000 American lives were lost due to overdoses, and the number is growing rapidly. Dr. Paulozzi also testified that all available evidence suggests that unintentional overdose deaths are related to the increasing use of prescription drugs, especially opioid painkillers.[20]

See alsoEdit


ReferencesEdit

  1. http://www.treatment-now.com/resources/definitions/
  2. 2.0 2.1 http://www.uphs.upenn.edu/addiction/berman/glossary/
  3. Study on fatal overdose in New-York City 1990-2000, visited May 11, 2008
  4. "What to do with leftover medicines". Medicines Talk, Winter 2005. Available at http://www.nps.org.au/consumers/publications/medicines_talk/mt14/what_to_do_with_left-over_medicines2
  5. Goldfrank, Lewis R. (1998). Goldfrank's toxicologic emergencies, Norwalk, CT: Appleton & Lange.
  6. Chandler, Stephanie Symptoms of an opiate overdose. Live Strong. URL accessed on 17 May 2012.
  7. Column - Fatal Drug-Drug Interaction As a Differential Consideration in Apparent Suicides
  8. Piper TM (2008). Evaluation of a naloxone distribution and administration program in New York City. Subst Use Misuse 43 (7): 858–870.
  9. OD Prevention Program Locator.. Overdose Prevention Alliance. URL accessed on 15 May 2012.
  10. (2010 Dec)Community-Based Opioid Overdose Prevention Programs Providing Naloxone — United States, 2010. Centers for Disease Control and Prevention.
  11. Albert S, Brason FW 2nd, Sanford CK, Dasgupta N, Graham J, Lovette B. (2011 Jun). Project Lazarus: community-based overdose prevention in rural North Carolina. Pain Medicine.
  12. Beletsky L, Burris S, and Kral AH. (2009 Jul). Closing Death's Door: Action Steps to Facilitate Emergency Opioid Drug Overdose Reversal in the United States. Center for Health Law, Policy and Practice, Temple University School of Law.
  13. Beletsky L, Ruthazer R, Macalino GE, Rich JD, Tan L, Burris S. (2007 Jan). Physicians' knowledge of and willingness to prescribe naloxone to reverse accidental opiate overdose: challenges and opportunities. Journal of Urban Health.
  14. Beletsky L, Moroz E. The Quincy Police Department: Pioneering Naloxone Among First Responders.. Overdose Prevention Alliance. URL accessed on 15 May 2012.
  15. Lavoie D. (2012 April). Naloxone: Drug-Overdose Antidote Is Put In Addicts' Hands. Huffington Post.
  16. Longmore, Murray; Ian Wilkinson, Tom Turmezei, Chee Kay Cheung (2007). Oxford Handbook of Clinical Medicine, United Kingdom: Oxford.
  17. 17.0 17.1 Vanden Hoek, TL, Morrison, LJ, Shuster, M, Donnino, M, Sinz, E, Lavonas, EJ, Jeejeebhoy, FM, Gabrielli, A (2010 Nov 2). Part 12: cardiac arrest in special situations: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 122 (18 Suppl 3): S829–61.
  18. National Center for Health Statistics
  19. Centers for Disease Control and Prevention
  20. Centers for Disease Control and Prevention


Further readingEdit

  • Nelson, Lewis H.; Flomenbaum, Neal; Goldfrank, Lewis R.; Hoffman, Robert Louis; Howland, Mary Deems; Neal A. Lewin (2006). Goldfrank's toxicologic emergencies, New York: McGraw-Hill, Medical Pub. Division.
  • Olson, Kent C. (2004). Poisoning & drug overdose, New York: Lange Medical Mooks/McGraw-Hill.

External linksEdit

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Wiktionary: overdose

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