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Dopamine beta-hydroxylase

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Dopamine beta-hydroxylase (dopamine beta-monooxygenase)
Identifiers
Symbol(s) DBH; DBM
External IDs OMIM: 609312 MGI94864 Homologene615
EC number 1.14.17.1
RNA expression pattern

250px

More reference expression data

Orthologs
Human Mouse Entrez 1621 13166 Ensembl ENSG00000123454 ENSMUSG00000000889 Uniprot P09172 Q3V1U4 Refseq NM_000787 (mRNA)
NP_000778 (protein)
NM_138942 (mRNA)
NP_620392 (protein)
Location Chr 9: 135.49 - 135.51 Mb Chr 2: 26.99 - 27 Mb
Pubmed search [1] [2]

Dopamine β-hydroxylase (DBH) is an enzyme that converts dopamine to norepinephrine:

DBH is a 290 kDa copper-containing oxygenase consisting of four identical subunits, and its activity requires ascorbate as a cofactor. [1] It is the only enzyme involved in the synthesis of small-molecule neurotransmitters that is membrane-bound, making norepinephrine and epinephrine the only transmitters synthesized inside vesicles. It is expressed in noradrenergic nerve terminals of the central and peripheral nervous systems, as well as in chromaffin cells of the adrenal medulla.

DBH is inhibited by disulfiram, [2] tropolone, [3] and, most selectively, by nepicastat. [4]

See alsoEdit

ReferencesEdit

  1. Rush RA, Geffen LB (1980). Dopamine beta-hydroxylase in health and disease.. Crit Rev Clin Lab Sci. 12 (3): 241-77.
  2. Goldstein M, Anagnoste B, Lauber E, McKeregham MR (1964). Inhibition of dopamine-beta-hydroxylase by Disulfiram.. Life Sci 3: 763-7.
  3. Goldstein M, Lauber E, McKeregham MR (1964). Inhibition of dopamine-beta-hydroxylase by tropolone and other chelating agents.. Biochem Pharmacol 13: 1103-6.
  4. Stanley WC et al. (1997). Catecholamine modulatory effects of nepicastat (RS-25560-197), a novel, potent and selective inhibitor of dopamine-beta-hydroxylase. 121 (8): 1803-9.

External linksEdit


  1. REDIRECT Template:Dioxygenases


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