Wikia

Psychology Wiki

Dihydroxyphenylacetic acid

Talk0
34,135pages on
this wiki
Revision as of 19:36, February 11, 2008 by Dr Joe Kiff (Talk | contribs)

Assessment | Biopsychology | Comparative | Cognitive | Developmental | Language | Individual differences | Personality | Philosophy | Social |
Methods | Statistics | Clinical | Educational | Industrial | Professional items | World psychology |

Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)


DOPAC (dihydroxyphenylacetic acid) is a metabolite of dopamine. The dopaminergic pathway consists of the following:


             ----> via MAO -> '''DOPAC''' -> via COMT 
           /                                    \
'''Dopamine (DA)''' . . . . . . . . . . . . . . . . . . .  . . . . . . . . . . . . . . . . ---> '''homovanillic acid (HVA)'''
           \                                    /    
             ----> via COMT -> '''3-MT''' -> via MAO 

One of the three direct products from the alteration of dopamine (DOPAC, 3-MT (3-methoxytyramine) and noradrenaline) DOPAC is an important metabolite when studying the behaviour of the dopaminergic system for multiple reasons; 3-MT is generally more difficult to assay alongside dopamine and by assessing all three metabolites (DOPAC, HVA and 3-MT) abnormalities in either COMT (catechol-O-methyl transferase) or MAO (monoamine oxidase) can be indirectly identified. This has large ramifications as COMT abnormalities are suspected in various neuropsychiatric diseases including schizophrenia.

See also

Around Wikia's network

Random Wiki